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Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment.
Chiou, Kenneth L; DeCasien, Alex R; Rees, Katherina P; Testard, Camille; Spurrell, Cailyn H; Gogate, Aishwarya A; Pliner, Hannah A; Tremblay, Sébastien; Mercer, Arianne; Whalen, Connor J; Negrón-Del Valle, Josué E; Janiak, Mareike C; Bauman Surratt, Samuel E; González, Olga; Compo, Nicole R; Stock, Michala K; Ruiz-Lambides, Angelina V; Martínez, Melween I; Wilson, Melissa A; Melin, Amanda D; Antón, Susan C; Walker, Christopher S; Sallet, Jérôme; Newbern, Jason M; Starita, Lea M; Shendure, Jay; Higham, James P; Brent, Lauren J N; Montague, Michael J; Platt, Michael L; Snyder-Mackler, Noah.
Afiliación
  • Chiou KL; Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA. chiou@asu.edu.
  • DeCasien AR; School of Life Sciences, Arizona State University, Tempe, AZ, USA. chiou@asu.edu.
  • Rees KP; Department of Psychology, University of Washington, Seattle, WA, USA. chiou@asu.edu.
  • Testard C; Nathan Shock Center of Excellence in the Basic Biology of Aging, University of Washington, Seattle, WA, USA. chiou@asu.edu.
  • Spurrell CH; Department of Anthropology, New York University, New York, NY, USA. alex.decasien@nyu.edu.
  • Gogate AA; New York Consortium in Evolutionary Primatology, New York, NY, USA. alex.decasien@nyu.edu.
  • Pliner HA; School of Life Sciences, Arizona State University, Tempe, AZ, USA.
  • Tremblay S; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.
  • Mercer A; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.
  • Whalen CJ; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.
  • Negrón-Del Valle JE; Seattle Children's Research Institute, Seattle, WA, USA.
  • Janiak MC; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.
  • Bauman Surratt SE; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.
  • González O; Department of Psychology, University of Washington, Seattle, WA, USA.
  • Compo NR; Department of Anthropology, New York University, New York, NY, USA.
  • Stock MK; School of Life Sciences, Arizona State University, Tempe, AZ, USA.
  • Ruiz-Lambides AV; School of Science, Engineering, & Environment, University of Salford, Salford, UK.
  • Martínez MI; Caribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA.
  • Wilson MA; Caribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA.
  • Melin AD; Department of Sociology and Anthropology, Metropolitan State University of Denver, Denver, CO, USA.
  • Antón SC; Caribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA.
  • Walker CS; Caribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA.
  • Newbern JM; Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA.
  • Starita LM; School of Life Sciences, Arizona State University, Tempe, AZ, USA.
  • Shendure J; Department of Anthropology and Archaeology, University of Calgary, Calgary, Alberta, Canada.
  • Higham JP; Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada.
  • Brent LJN; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.
  • Montague MJ; Department of Anthropology, New York University, New York, NY, USA.
  • Platt ML; New York Consortium in Evolutionary Primatology, New York, NY, USA.
  • Snyder-Mackler N; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Nat Neurosci ; 25(12): 1714-1723, 2022 12.
Article en En | MEDLINE | ID: mdl-36424430
ABSTRACT
Aging is accompanied by a host of social and biological changes that correlate with behavior, cognitive health and susceptibility to neurodegenerative disease. To understand trajectories of brain aging in a primate, we generated a multiregion bulk (N = 527 samples) and single-nucleus (N = 24 samples) brain transcriptional dataset encompassing 15 brain regions and both sexes in a unique population of free-ranging, behaviorally phenotyped rhesus macaques. We demonstrate that age-related changes in the level and variance of gene expression occur in genes associated with neural functions and neurological diseases, including Alzheimer's disease. Further, we show that higher social status in females is associated with younger relative transcriptional ages, providing a link between the social environment and aging in the brain. Our findings lend insight into biological mechanisms underlying brain aging in a nonhuman primate model of human behavior, cognition and health.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article