Further undescribed cembranoids from South China Sea soft coral Sarcophyton ehrenbergi: Structural elucidation and biological evaluation.
Phytochemistry
; 206: 113549, 2023 Feb.
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| ID: mdl-36481314
ABSTRACT
A detailed chemical investigation of the South China Sea soft coral Sarcophyton ehrenbergi has yield seven undescribed cembranoids, namely isoehrenbergol D and sarcoehrenolides F-K embodying a rare α,ß-unsaturated-lactone moiety at C-6 to C-19, along with two known related compounds, ehrenbergol D and sarcoehrenolide A. Their structures and absolute configurations were unambiguously established in the light of extensive spectroscopic data analysis, modified Mosher's method, X-ray diffraction analysis, and quantum chemical computation method. In a bioassay for α-glucosidase inhibition, ehrenbergol D was evaluated as α-glucosidase inhibitor with an IC50 value of 13.57 µM.
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Base de datos:
MEDLINE
Asunto principal:
Antozoos
/
Diterpenos
País/Región como asunto:
Asia
Idioma:
En
Revista:
Phytochemistry
Año:
2023
Tipo del documento:
Article