External and Environmental Effects on Centrosomes.
Adv Anat Embryol Cell Biol
; 235: 81-83, 2022.
Article
en En
| MEDLINE
| ID: mdl-36525114
ABSTRACT
The effects of ionizing radiation on centrosomes have been well documented and reviewed by Saladino et al. (2012) and are only briefly addressed here. These results showed that exposure of tumor cells to ionizing radiation causes centrosome overduplication and the formation of multipolar mitotic spindles, resulting in nuclear fragmentation and subsequent cell death (Sato et al. 2000). By using a variety of cell lines derived from different types of human solid tumors, it was shown that exposure to 10 Gy γ-radiation resulted in a substantial increase in cells containing an abnormally high number of aberrant centrosomes that formed multipolar spindles, resulting in imbalanced chromosome separation followed by mitotic cell death and formation of multi- or micronucleated cells.
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Base de datos:
MEDLINE
Asunto principal:
Centrosoma
/
Huso Acromático
Idioma:
En
Revista:
Adv Anat Embryol Cell Biol
Año:
2022
Tipo del documento:
Article