Re-understanding and focusing on normoalbuminuric diabetic kidney disease.
Front Endocrinol (Lausanne)
; 13: 1077929, 2022.
Article
en En
| MEDLINE
| ID: mdl-36531487
ABSTRACT
Diabetes mellitus (DM) has grown up to be an important issue of global public health because of its high incidence rate. About 25% of DM patients can develop diabetic foot/ulcers (DF/DFU). Diabetic kidney disease (DKD) is the main cause of end-stage kidney disease (ESKD). DF/DFU and DKD are serious complications of DM. Therefore, early diagnosis and timely prevention and treatment of DF/DFU and DKD are essential for the progress of DM. The clinical diagnosis and staging of DKD are mostly based on the urinary albumin excretion rate (UAER) and EGFR. However, clinically, DKD patients show normoalbuminuric diabetic kidney disease (NADKD) instead of clinical proteinuria. The old NADKD concept is no longer suitable and should be updated accordingly with the redefinition of normal proteinuria by NKF/FDA. Based on the relevant guidelines of DM and CKD and combined with the current situation of clinical research, the review described NADKD from the aspects of epidemiology, pathological mechanism, clinical characteristics, biomarkers, disease diagnosis, and the relationship with DF/DFU to arouse the new understanding of NADKD in the medical profession and pay attention to it.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Pie Diabético
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Diabetes Mellitus
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Nefropatías Diabéticas
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Fallo Renal Crónico
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Guideline
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Screening_studies
Idioma:
En
Revista:
Front Endocrinol (Lausanne)
Año:
2022
Tipo del documento:
Article