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MRI characteristics for predicting histological subtypes in patients with uterine cervical adenocarcinoma.
Mori, Takayuki; Kato, Hiroki; Kawaguchi, Masaya; Kanayama, Tomohiro; Furui, Tatsuro; Noda, Yoshifumi; Hyodo, Fuminori; Matsuo, Masayuki.
Afiliación
  • Mori T; Department of Radiology, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
  • Kato H; Department of Radiology, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan. Electronic address: hkato@gifu-u.ac.jp.
  • Kawaguchi M; Department of Radiology, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
  • Kanayama T; Department of Pathology, Gifu University, Gifu, Japan.
  • Furui T; Department of Obstetrics and Gynecology, Gifu University, Gifu, Japan.
  • Noda Y; Department of Radiology, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
  • Hyodo F; Department of Radiology, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan; Institute for Advanced Study, Gifu University, Japan.
  • Matsuo M; Department of Radiology, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
Eur J Radiol ; 158: 110612, 2023 Jan.
Article en En | MEDLINE | ID: mdl-36542931
PURPOSE: To evaluate the magnetic resonance imaging (MRI) findings of uterine cervical adenocarcinoma for predicting different histological subtypes. MATERIALS AND METHODS: We retrospectively analyzed MRI findings of 76 consecutive patients with histopathologically-confirmed uterine cervical adenocarcinoma undergoing preoperative MRI examination. An experienced pathologist classified the histological subtypes based on World Health Organization's 2020 classification and into human papillomavirus (HPV)-associated adenocarcinomas (HPVAs, n = 54) (usual type and variants) and HPV-independent adenocarcinomas (HPVIs, n = 22) (gastric type adenocarcinoma (GAS), clear cell type, and other types). Different MRI variables were compared quantitatively and qualitatively between HPVA and HPVI and between GAS and non-GAS tumor types. RESULTS: The maximum tumor diameter was significantly greater in HPVIs than HPVAs (41.9 ± 18.6 vs 32.7 ± 15.6 mm; p < 0.05). Heterogeneous enhancement on fat-suppressed gadolinium-enhanced T1-weighted images was more frequently seen in HPVIs than HPVAs (62 % vs 15 %; p < 0.01) and in GASs than non-GASs (78 % vs 16 %; p < 0.01). Also, infiltrative growth pattern (58 % vs 20 %; p < 0.05) and intratumoral cyst formation (83 % vs 47 %) (p < 0.05) were more frequent in GASs than non-GASs. CONCLUSIONS: Compared with HPVAs, HPVIs tend to have a larger tumor size with heterogeneous enhancement, of which GASs frequently show infiltrative growth patterns with intratumoral cyst formation and heterogeneous enhancement.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Neoplasias Uterinas / Adenocarcinoma / Neoplasias del Cuello Uterino / Quistes / Infecciones por Papillomavirus Tipo de estudio: Observational_studies / Prognostic_studies Idioma: En Revista: Eur J Radiol Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Neoplasias Uterinas / Adenocarcinoma / Neoplasias del Cuello Uterino / Quistes / Infecciones por Papillomavirus Tipo de estudio: Observational_studies / Prognostic_studies Idioma: En Revista: Eur J Radiol Año: 2023 Tipo del documento: Article