Endothelial dysfunction in subfertile women with polycystic ovary syndrome.
Reprod Biomed Online
; 46(2): 391-398, 2023 02.
Article
en En
| MEDLINE
| ID: mdl-36566144
ABSTRACT
RESEARCH QUESTION Is there an association between post-occlusive reactive hyperaemia (PORH) and ovarian stimulation in women with normoandrogenaemic polycystic ovary syndrome (PCOS)? DESIGN:
Women eligible for IVF at an academic fertility centre were invited to join this prospective study. Microvascular endothelial function was measured as PORH by laser Doppler flowmetry (LDF) before and after ovarian stimulation. Metabolic characteristics, hormone profiles and biochemical markers were analysed.RESULTS:
Thirty-four normoandrogenaemic women with PCOS and 36 normoandrogenaemic women without PCOS were included. The PCOS group displayed higher C-reactive protein levels and insulin resistance (Pâ¯=â¯0.048 and Pâ¯=â¯0.025, respectively). No significant difference was found in microcirculatory function between the groups at baseline. After ovarian stimulation, PORH was enhanced in the control group (slope 7.1 ± 3.3 versus 9.7 ± 4.5; Pâ¯=â¯0.007; peak flow 30.7 ± 16.3 versus 43.5 ± 17.3, Pâ¯=â¯0.008; however, the PCOS group experienced a blunting response to supraphysiological hormone status (slope 8.2 ± 5.1 versus 7.2 ± 4.3, Pâ¯=â¯0.212; peak flow, 38.8 ± 19.4 versus 37.0 ± 21.8, Pâ¯=â¯0.895).CONCLUSIONS:
Impaired microcirculatory function could be found using a non-invasive LDF technique in normoandrogenaemic women with PCOS undergoing IVF, indicating early changes in vascular endothelial dysfunction. Future observational studies should clarify whether PORH measurement might help predict IVF prognosis or obstetric complications.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Síndrome del Ovario Poliquístico
/
Infertilidad
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Reprod Biomed Online
Asunto de la revista:
MEDICINA REPRODUTIVA
Año:
2023
Tipo del documento:
Article