Anti-Langmuir elution behavior of a bispecific monoclonal antibody in cation exchange chromatography: Mechanistic modeling using a pH-dependent Self-Association Steric Mass Action isotherm.

Seelinger, Felix; Wittkopp, Felix; von Hirschheydt, Thomas; Frech, Christian

Seelinger, Felix; Wittkopp, Felix; von Hirschheydt, Thomas; Frech, Christian.

Afiliación

Seelinger F; Institute for Biochemistry, University of Applied Sciences Mannheim, 68163 Mannheim, Germany.
Wittkopp F; Roche Diagnostics GmbH, Pharma Research and Early Development (pRED), Large Molecule Research (LMR), Roche Innovation Center Munich, 82377 Penzberg, Germany.
von Hirschheydt T; Roche Diagnostics GmbH, Bioprocess Development, 82377 Penzberg, Germany.
Frech C; Institute for Biochemistry, University of Applied Sciences Mannheim, 68163 Mannheim, Germany. Electronic address: c.frech@hs-mannheim.de.

J Chromatogr A ; 1689: 463730, 2023 Jan 25.

Article en En | MEDLINE | ID: mdl-36592480

Asunto(s)

Anticuerpos Biespecíficos; Anticuerpos Monoclonales; Cromatografía por Intercambio Iónico; Anticuerpos Monoclonales/metabolismo; Cloruro de Sodio; Cationes; Resinas de Intercambio de Catión; Concentración de Iones de Hidrógeno

Palabras clave

Self-Association Steric Mass Action model; anti-Langmuir; bispecific monoclonal antibody; cation exchange chromatography; pH-dependence

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Anticuerpos Biespecíficos / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Chromatogr A Año: 2023 Tipo del documento: Article

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