Involvement of ERCC1 (rs3212986) and ERCC2 (rs1799793, rs13181) polymorphisms of DNA repair genes in breast cancer occurrence in Burkina Faso.
Mol Genet Genomic Med
; 11(4): e2134, 2023 04.
Article
en En
| MEDLINE
| ID: mdl-36594475
ABSTRACT
BACKGROUND:
Genetic alterations can result in DNA repair defects, increasing susceptibility to breast cancer. The aim of this study was to evaluate the involvement of two DNA repair genes, ERCC1 (rs3212986, GenBank NC_000073.9) and ERCC2 (rs1799793, rs13181, GenBank NC_000019.10) in the occurrence of breast cancer in Burkina Faso.METHODS:
This case-control study enrolled 128 participants including 64 patients and 64 healthy controls. Genotyping of polymorphisms were performed by real-time PCR and PCR-RFLP.RESULTS:
The heterozygous AC genotype of the ERCC2rs13181 polymorphism was associated with the occurrence of breast cancer when the mutant allele is inherited under the dominant pattern (CC/AC vs AA; OR = 2.74, 95% IC (1.09-6.87); p = .028), but this association became insignificant after the Bonferroni correction (p = .156). No association was observed between ERCC1rs3212986 and ERCC2rs1799793 polymorphisms and breast cancer risk.CONCLUSION:
This study showed that the heterozygous genotype (CA) of the ERCC2rs13181 polymorphism may be associated with a risk of breast cancer.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Proteínas de Unión al ADN
/
Endonucleasas
/
Proteína de la Xerodermia Pigmentosa del Grupo D
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
País/Región como asunto:
Africa
Idioma:
En
Revista:
Mol Genet Genomic Med
Año:
2023
Tipo del documento:
Article