Distinct conformational changes occur within the intrinsically unstructured pro-domain of pro-Nerve Growth Factor in the presence of ATP and Mg<sup>2</sup>.

Paoletti, Francesca; Covaceuszach, Sonia; Cassetta, Alberto; Calabrese, Antonio N; Novak, Urban; Konarev, Petr; Grdadolnik, Joze; Lamba, Doriano; Golic Grdadolnik, Simona

Distinct conformational changes occur within the intrinsically unstructured pro-domain of pro-Nerve Growth Factor in the presence of ATP and Mg².

Paoletti, Francesca; Covaceuszach, Sonia; Cassetta, Alberto; Calabrese, Antonio N; Novak, Urban; Konarev, Petr; Grdadolnik, Joze; Lamba, Doriano; Golic Grdadolnik, Simona.

Afiliación

Paoletti F; Laboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, Ljubljana, Slovenia.
Covaceuszach S; Institute of Crystallography-C.N.R.-Trieste Outstation, Trieste, Italy.
Cassetta A; Institute of Crystallography-C.N.R.-Trieste Outstation, Trieste, Italy.
Calabrese AN; School of Molecular and Cellular Biology, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.
Novak U; Laboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, Ljubljana, Slovenia.
Konarev P; A.V. Shubnikov Institute of Crystallography of Federal Scientific Research Centre "Crystallography and Photonics", Russian Academy of Sciences, Moscow, Russia.
Grdadolnik J; Laboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, Ljubljana, Slovenia.
Lamba D; Institute of Crystallography-C.N.R.-Trieste Outstation, Trieste, Italy.
Golic Grdadolnik S; Interuniversity Consortium "Biostructures and Biosystems National Institute", Rome, Italy.

Protein Sci ; 32(2): e4563, 2023 02.

Article en En | MEDLINE | ID: mdl-36605018

Asunto(s)

Factor de Crecimiento Nervioso; Neuronas; Factor de Crecimiento Nervioso/química; Factor de Crecimiento Nervioso/metabolismo; Dominios Proteicos; Neuronas/metabolismo; Adenosina Trifosfato

Palabras clave

Hydrogen-Deuterium eXchange-Mass Spectrometry (HDX-MS); NMR spectroscopy; Small Angle X-ray Scattering (SAXS); conformational rearrangement of the Intrinsically Unstructured Domain (IUD); intermolecular interactions; proNGF

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Factor de Crecimiento Nervioso / Neuronas Idioma: En Revista: Protein Sci Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google