Selective ATM inhibition augments radiation-induced inflammatory signaling and cancer cell death.

Chiu, Li-Ya; Sun, Qing; Zenke, Frank T; Blaukat, Andree; Vassilev, Lyubomir T

Chiu, Li-Ya; Sun, Qing; Zenke, Frank T; Blaukat, Andree; Vassilev, Lyubomir T.

Afiliación

Chiu LY; Translational Innovation Platform Oncology and Immuno-Oncology, EMD Serono, Billerica, MA 01821, USA.
Sun Q; Translational Innovation Platform Oncology and Immuno-Oncology, EMD Serono, Billerica, MA 01821, USA.
Zenke FT; Translational Innovation Platform Oncology and Immuno-Oncology, The Healthcare Business of Merck KGaA, Darmstadt, Hesse, Germany.
Blaukat A; Translational Innovation Platform Oncology and Immuno-Oncology, The Healthcare Business of Merck KGaA, Darmstadt, Hesse, Germany.
Vassilev LT; Translational Innovation Platform Oncology and Immuno-Oncology, EMD Serono, Billerica, MA 01821, USA.

Aging (Albany NY) ; 15(2): 492-512, 2023 01 17.

Article en En | MEDLINE | ID: mdl-36656721

Asunto(s)

Ataxia Telangiectasia; Neoplasias; Animales; Humanos; Antígeno B7-H1/genética; Proteínas de la Ataxia Telangiectasia Mutada/metabolismo; Fosforilación; Muerte Celular; Proteínas de Ciclo Celular/metabolismo; Daño del ADN; Neoplasias/tratamiento farmacológico; Neoplasias/radioterapia

Palabras clave

ATM; STING; cell cycle; micronuclei; radiation therapy

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ataxia Telangiectasia / Neoplasias Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2023 Tipo del documento: Article

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