Your browser doesn't support javascript.
loading
Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia.
Cheon, Eun-Jin; Male, Alie G; Gao, Bingchen; Adhikari, Bhim M; Edmond, Jesse T; Hare, Stephanie M; Belger, Aysenil; Potkin, Steven G; Bustillo, Juan R; Mathalon, Daniel H; Ford, Judith M; Lim, Kelvin O; Mueller, Bryon A; Preda, Adrian; O'Leary, Daniel; Strauss, Gregory P; Ahmed, Anthony O; Thompson, Paul M; Jahanshad, Neda; Kochunov, Peter; Calhoun, Vince D; Turner, Jessica A; van Erp, Theo G M.
Afiliación
  • Cheon EJ; Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States; Department of Psychiatry, Yeungnam University College of Medicine, Daegu, South Korea.
  • Male AG; Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States.
  • Gao B; Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States.
  • Adhikari BM; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, United States.
  • Edmond JT; Center for Translational Research in Neuroimaging and Data Science (TReNDS), GSU/GATech/Emory, Atlanta, GA, United States.
  • Hare SM; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, United States.
  • Belger A; Department of Psychiatry, University of North Carolina, Chapel Hill, United States.
  • Potkin SG; Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States.
  • Bustillo JR; Departments of Psychiatry & Neuroscience, University of New Mexico, Albuquerque, NM, United States.
  • Mathalon DH; Department of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, CA, United States; Veterans Affairs San Francisco Healthcare System, San Francisco, CA, United States.
  • Ford JM; Department of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, CA, United States; Veterans Affairs San Francisco Healthcare System, San Francisco, CA, United States.
  • Lim KO; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States.
  • Mueller BA; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States.
  • Preda A; Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States.
  • O'Leary D; Department of Psychiatry, University of Iowa, IA, United States.
  • Strauss GP; Department of Psychology, University of Georgia, Athens, GA, United States.
  • Ahmed AO; Department of Psychiatry, Weill Cornell Medicine, White Plains, NY, United States.
  • Thompson PM; Imaging Genetics Center, University of Southern California, Marina del Rey, CA, United States.
  • Jahanshad N; Imaging Genetics Center, University of Southern California, Marina del Rey, CA, United States.
  • Kochunov P; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, United States.
  • Calhoun VD; Center for Translational Research in Neuroimaging and Data Science (TReNDS), GSU/GATech/Emory, Atlanta, GA, United States.
  • Turner JA; Department of Psychiatry, Ohio State University, OH, United States.
  • van Erp TGM; Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States; Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA, United States. Electronic address: tv
Psychiatry Res Neuroimaging ; 329: 111597, 2023 03.
Article en En | MEDLINE | ID: mdl-36680843
ABSTRACT
This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Esquizofrenia Tipo de estudio: Diagnostic_studies / Risk_factors_studies Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Esquizofrenia Tipo de estudio: Diagnostic_studies / Risk_factors_studies Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2023 Tipo del documento: Article