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Tight control in patients with rheumatoid arthritis treated with targeted therapies across the COVID-19 pandemic era.
Luppino, Angela Flavia; Cincinelli, Gilberto; Orenti, Annalisa; Boracchi, Patrizia; Favalli, Ennio Giulio; Caporali, Roberto; Ingegnoli, Francesca.
Afiliación
  • Luppino AF; Clinical Rheumatology Unit, ASST Gaetano Pini-CTO, Department of Clinical Sciences & Community Health, Università degli Studi di Milano, Milano, Italy.
  • Cincinelli G; Clinical Rheumatology Unit, ASST Gaetano Pini-CTO, Department of Clinical Sciences & Community Health, Università degli Studi di Milano, Milano, Italy.
  • Orenti A; Lab of Medical Statistics, Biometry and Epidemiology "GA Maccacaro", Department of Clinical Sciences & Community Health, Università degli Studi di Milano, Milano, Italy.
  • Boracchi P; Department of Biomedical and Clinical Sciences "L. Sacco", Università degli Studi di Milano, Milano, Italy.
  • Favalli EG; Clinical Rheumatology Unit, ASST Gaetano Pini-CTO, Department of Clinical Sciences & Community Health, Università degli Studi di Milano, Milano, Italy.
  • Caporali R; Clinical Rheumatology Unit, ASST Gaetano Pini-CTO, Department of Clinical Sciences & Community Health, Università degli Studi di Milano, Milano, Italy.
  • Ingegnoli F; Clinical Rheumatology Unit, ASST Gaetano Pini-CTO, Department of Clinical Sciences & Community Health, Università degli Studi di Milano, Milano, Italy.
J Telemed Telecare ; : 1357633X221150724, 2023 Jan 24.
Article en En | MEDLINE | ID: mdl-36694430
OBJECTIVES: To analyze the impact of different patterns of healthcare delivery on remission of rheumatoid arthritis (RA) patients treated with targeted therapies during the first wave (2020) and second/third waves (2021) of the pandemic compared to the pre-pandemic period (2019). METHODS: In this observational real-life study, data from RA patients treated with biologic or targeted synthetic drugs were extracted from a longitudinal registry. Clinical Disease Activity Index (CDAI) was analyzed in the same period from the 22nd of February to the 18th of May for three consecutive years. These three periods were characterized by different patterns of healthcare delivery: (1) before the pandemic (2019) only in-person visits, (2) during the first wave (2020) both in-person visits and telehealth, and (3) during the second/third waves (2021) only in-person visits. A generalized linear model with the binomial error was fitted to evaluate the difference in the proportion of patients in CDAI remission. Quantile regression was used to compare the median of CDAI in difficult-to-treat (D2T) patients. RESULTS: In the three periods, we included 407, 450, and 540 RA patients respectively. The percentages of patients in CDAI remission were similar in the three periods (prevalence ratio 1.07, p value 0.423 between 2020 and 2019, and 1.01, p-value 0.934 between 2021 and 2019). The CDAI remission rate was 40.55% (N = 163), 43.18% (N = 155) and 40.82% (N = 220) in 2019, 2020 and 2021, respectively. Among our cohort of D2T patients, CDAI remission was similar across the three periods (N = 30, 22.22%; N = 27, 23.68%; and N = 34, 21.52% respectively). CONCLUSION: Although the pandemic has imposed changes in our healthcare delivery, these different strategies seem to be effective in ensuring satisfactory management of RA treated with targeted therapies. The approaches modulated in the context of the different periods have been a feasible compensation for ensuring disease control even in D2T patients.
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Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: J Telemed Telecare Asunto de la revista: INFORMATICA MEDICA / SERVICOS DE SAUDE Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: J Telemed Telecare Asunto de la revista: INFORMATICA MEDICA / SERVICOS DE SAUDE Año: 2023 Tipo del documento: Article