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New Cerebral Microbleeds After Catheter-Based Structural Heart Interventions: An Exploratory Analysis.
Braemswig, Tim Bastian; Kusserow, Madeleine; Bellmann, Barbara; Beckhoff, Frederik; Reinthaler, Markus; von Rennenberg, Regina; Erdur, Hebun; Scheitz, Jan F; Galinovic, Ivana; Villringer, Kersten; Leistner, David M; Audebert, Heinrich J; Endres, Matthias; Landmesser, Ulf; Haeusler, Karl Georg; Fiebach, Jochen B; Lauten, Alexander; Rillig, Andreas; Nolte, Christian H.
Afiliación
  • Braemswig TB; Klinik und Hochschulambulanz für Neurologie Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
  • Kusserow M; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin Berlin Germany.
  • Bellmann B; Center for Stroke Research Berlin (CSB) Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
  • Beckhoff F; German Centre for Cardiovascular Research (DZHK), partner site Berlin Berlin Germany.
  • Reinthaler M; Klinik für Innere Medizin Bundeswehrkrankenhaus Berlin Berlin Germany.
  • von Rennenberg R; Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
  • Erdur H; MEDIAN Klinik AGZ Düsseldorf Düsseldorf Germany.
  • Scheitz JF; Department of Cardiology Campus Benjamin Franklin Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
  • Galinovic I; Department of Cardiology Campus Benjamin Franklin Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
  • Villringer K; Department of Cardiology Campus Benjamin Franklin Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
  • Leistner DM; Institute of Active Polymers and Berlin-Brandenburg Center for Regenerative Therapies Helmholtz-Zentrum Hereon Teltow Germany.
  • Audebert HJ; Deutsches Herzzentrum der Charité, Klinik für Kardiologie Angiologie und Intensivmedizin Berlin Germany.
  • Endres M; Klinik und Hochschulambulanz für Neurologie Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
  • Landmesser U; Center for Stroke Research Berlin (CSB) Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
  • Haeusler KG; German Center for Neurodegenerative Diseases (DZNE), partner site Berlin Berlin Germany.
  • Fiebach JB; Klinik und Hochschulambulanz für Neurologie Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
  • Lauten A; Center for Stroke Research Berlin (CSB) Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
  • Rillig A; Klinik und Hochschulambulanz für Neurologie Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
  • Nolte CH; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin Berlin Germany.
J Am Heart Assoc ; 12(3): e8189, 2023 02 07.
Article en En | MEDLINE | ID: mdl-36734351
Background Cerebral microbleeds (CMBs) are increasingly recognized as "covert" brain lesions indicating increased risk of future neurological events. However, data on CMBs in patients undergoing catheter-based structural heart interventions are scarce. Therefore, we assessed occurrence and predictors of new CMBs in patients undergoing catheter-based left atrial appendage closure and percutaneous mitral valve repair using the MitraClip System. Methods and Results We conducted an exploratory analysis using data derived from 2 prospective, observational studies. Eligible patients underwent cerebral magnetic resonance imaging (3 Tesla) examinations and cognitive tests (using the Montreal Cognitive Assessment) before and after catheter-based left atrial appendage closure and percutaneous mitral valve repair. Forty-seven patients (53% men; median age, 77 years) were included. New CMBs occurred in 17 of 47 patients (36%) following catheter-based structural heart interventions. Occurrences of new CMBs did not differ significantly between patients undergoing catheter-based left atrial appendage closure and percutaneous mitral valve repair (7/25 versus 10/22; P=0.348). In univariable analysis, longer procedure time was significantly associated with new CMBs. Adjustment for heparin attenuated this association (adjusted odds ratio [per 30 minutes]: 1.77 [95% CI, 0.92-3.83]; P=0.090). Conclusions New CMBs occur in approximately one-third of patients after catheter-based left atrial appendage closure and percutaneous mitral valve repair using the MitraClip System. Our data suggest that longer duration of the procedure may be a risk factor for new CMBs. Future studies in larger populations are needed to further investigate their clinical relevance. Clinical Trial Registration German Clinical Trials Register: DRKS00010300 (https://drks.de/search/en/trial/DRKS00010300); ClinicalTrials.gov : NCT03104556 (https://clinicaltrials.gov/ct2/show/NCT03104556?term=NCT03104556&draw=2&rank=1).
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Procedimientos Quirúrgicos Cardíacos / Insuficiencia de la Válvula Mitral Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Am Heart Assoc Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Procedimientos Quirúrgicos Cardíacos / Insuficiencia de la Válvula Mitral Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Am Heart Assoc Año: 2023 Tipo del documento: Article