Microvascular Thrombosis as a Critical Factor in Severe COVID-19.
Int J Mol Sci
; 24(3)2023 Jan 27.
Article
en En
| MEDLINE
| ID: mdl-36768817
ABSTRACT
Platelet-endothelial interactions have a critical role in microcirculatory function, which maintains tissue homeostasis. The subtle equilibrium between platelets and the vessel wall is disturbed by the coronavirus disease 2019 (COVID-19), which affects all three components of Virchow's triad (endothelial injury, stasis and a hypercoagulable state). Endotheliitis, vasculitis, glycocalyx degradation, alterations in blood flow and viscosity, neutrophil extracellular trap formation and microparticle shedding are only few pathomechanisms contributing to endothelial damage and microthrombosis resulting in capillary plugging and tissue ischemia. In the following opinion paper, we discuss major pathological processes leading to microvascular endothelial activation and thrombosis formation as a possible major adverse factor driving the deterioration of patient disease course in severe COVID-19.
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Base de datos:
MEDLINE
Asunto principal:
Trombosis
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Trombofilia
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COVID-19
Idioma:
En
Revista:
Int J Mol Sci
Año:
2023
Tipo del documento:
Article