High producer variant of lipoprotein lipase may protect from hepatocellular carcinoma in alcohol-associated cirrhosis.

Schmalz, Franziska; Fischer, Janett; Innes, Hamish; Buch, Stephan; Möller, Christine; Matz-Soja, Madlen; von Schönfels, Witigo; Krämer, Benjamin; Langhans, Bettina; Klüners, Alexandra; Soyka, Michael; Stickel, Felix; Nattermann, Jacob; Strassburg, Christian P; Berg, Thomas; Lutz, Philipp; Nischalke, Hans Dieter

Schmalz, Franziska; Fischer, Janett; Innes, Hamish; Buch, Stephan; Möller, Christine; Matz-Soja, Madlen; von Schönfels, Witigo; Krämer, Benjamin; Langhans, Bettina; Klüners, Alexandra; Soyka, Michael; Stickel, Felix; Nattermann, Jacob; Strassburg, Christian P; Berg, Thomas; Lutz, Philipp; Nischalke, Hans Dieter.

Afiliación

Schmalz F; Department of Internal Medicine I, University Hospital, University of Bonn, Germany.
Fischer J; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.
Innes H; School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.
Buch S; Medical Department 1, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany.
Möller C; Department of Internal Medicine I, University Hospital, University of Bonn, Germany.
Matz-Soja M; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.
von Schönfels W; Department of General, Visceral-, Thoracic-, Transplantation- and Pediatric Surgery, University Medical Center Schleswig-Holstein (UKSH), Campus Kiel, and Christian-Albrecht University (CAU), Kiel, Germany.
Krämer B; Department of Internal Medicine I, University Hospital, University of Bonn, Germany.
Langhans B; Department of Internal Medicine I, University Hospital, University of Bonn, Germany.
Klüners A; Department of Internal Medicine I, University Hospital, University of Bonn, Germany.
Soyka M; Psychiatric Hospital, Ludwig Maximilians University, Munich, Germany.
Stickel F; Department of Gastroenterology and Hepatology, University Hospital of Zürich, Switzerland.
Nattermann J; Department of Internal Medicine I, University Hospital, University of Bonn, Germany.
Strassburg CP; Department of Internal Medicine I, University Hospital, University of Bonn, Germany.
Berg T; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.
Lutz P; Department of Internal Medicine I, University Hospital, University of Bonn, Germany.
Nischalke HD; Department of Internal Medicine I, University Hospital, University of Bonn, Germany.

JHEP Rep ; 5(4): 100684, 2023 Apr.

Article en En | MEDLINE | ID: mdl-36879887

Palabras clave

ALD, alcohol-associated liver disease; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Alcohol-associated liver disease; BCLC, Barcelona Clinic Liver Cancer; BSA, bovine serum albumin; Cirrhosis; FCS, foetal calf serum; FIB-4, fibrosis 4; GADPH, glyceraldehyde 3-phosphate dehydrogenase; GGT, gamma-glutamyl transferase; HCC; HCC, hepatocellular carcinoma; HSCs, hepatic stellate cells; HbA1c, glycated haemoglobin; LPL; LPL, lipoprotein lipase; LSECs, liver sinusoidal endothelial cells; MAF, minor allele frequency; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; OR, odds ratio; PNPLA3, patatin-like phospholipase domain-containing protein 3; T2DM, type 2 diabetes mellitus; UKB, UK Biobank; rs13702; rs328

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Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: JHEP Rep Año: 2023 Tipo del documento: Article

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Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: JHEP Rep Año: 2023 Tipo del documento: Article