Hepatoprotective potential of gabapentin in cecal ligation and puncture-induced sepsis; targeting oxidative stress, apoptosis, and NF-kB/MAPK signaling pathways.

Abdelnaser, Mahmoud; Alaaeldin, Rania; Attya, Mina Ezzat; Fathy, Moustafa

Abdelnaser, Mahmoud; Alaaeldin, Rania; Attya, Mina Ezzat; Fathy, Moustafa.

Afiliación

Abdelnaser M; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: mahmoud.abdelnaser@deraya.edu.eg.
Alaaeldin R; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: rania.alaadin@deraya.edu.eg.
Attya ME; Department of Pathology, Faculty of Medicine, Minia University, Minia 61519, Egypt. Electronic address: mena.ezzat@mu.edu.eg.
Fathy M; Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt. Electronic address: mostafa_fathe@mu.edu.eg.

Life Sci ; 320: 121562, 2023 May 01.

Article en En | MEDLINE | ID: mdl-36907325

Asunto(s)

FN-kappa B; Sepsis; Ratas; Masculino; Animales; FN-kappa B/metabolismo; Caspasa 3/metabolismo; Gabapentina/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo; Sistema de Señalización de MAP Quinasas; Interleucina-6/metabolismo; Proteína X Asociada a bcl-2/metabolismo; Ratas Wistar; Transducción de Señal; Estrés Oxidativo; Punciones; Sepsis/complicaciones; Sepsis/tratamiento farmacológico; Sepsis/genética; Apoptosis

Palabras clave

Apoptosis; CLP; Cleaved caspase 3; Gabapentin; MAPK; NF-kB; TNF-α

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: FN-kappa B / Sepsis Tipo de estudio: Prognostic_studies Idioma: En Revista: Life Sci Año: 2023 Tipo del documento: Article

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