[Analysis of the effects of low/intermediate dose of coagulation factor â
§ on 30 adult patients with severe hemophilia A in a single center].
Zhonghua Xue Ye Xue Za Zhi
; 44(1): 38-42, 2023 Jan 14.
Article
en Zh
| MEDLINE
| ID: mdl-36987721
ABSTRACT
Objective:
To evaluate the clinical effects of low- and intermediate-dose factor â § (F â §) prophylaxis in Chinese adult patients with severe hemophilia A.Methods:
Thirty adult patients with severe hemophilia A who received low- (n=20) /intermediate-dose (n=10) F â § prophylaxis at Nanjing Drum Tower Hospital affiliated with Nanjing University Medical College were included in the study. The annual bleeding rate (ABR), annual joint bleeding rate (AJBR), number of target joints, functional independence score of hemophilia (FISH), quality of life score, and health status score (SF-36) before and after preventive treatment were retrospectively analyzed and compared.Results:
The median follow-up was 48 months. Compared with on-demand treatment, low- and intermediate-dose prophylaxis significantly reduced ABR, AJBR, and the number of target joints (P<0.05) ; the improvement in the intermediate-dose prophylaxis group was better than that in the low-dose prophylaxis group (P<0.05). Compared with on-demand treatment, the FISH score, quality of life score, and SF-36 score significantly improved in both groups (P<0.05), but there was no significant difference between the two groups (P>0.05) .Conclusion:
In Chinese adults with severe hemophilia A, low- and intermediate-dose prophylaxis can significantly reduce bleeding frequency, delay the progression of joint lesions, and improve the quality of life of patients as compared with on-demand treatment. The improvement in clinical bleeding was better with intermediate-dose prophylaxis than low-dose prophylaxis.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Hemofilia A
Tipo de estudio:
Observational_studies
Idioma:
Zh
Revista:
Zhonghua Xue Ye Xue Za Zhi
Año:
2023
Tipo del documento:
Article