Your browser doesn't support javascript.
loading
Unraveling Neuro-Proteogenomic Landscape and Therapeutic Implications for Human Behaviors and Psychiatric Disorders.
Repetto, Linda; Chen, Jiantao; Yang, Zhijian; Zhai, Ranran; Timmers, Paul R H J; Li, Ting; Twait, Emma L; May-Wilson, Sebastian; Muckian, Marisa D; Prins, Bram P; Png, Grace; Kooperberg, Charles; Johansson, Åsa; Hillary, Robert F; Wheeler, Eleanor; Pan, Lu; He, Yazhou; Klasson, Sofia; Ahmad, Shahzad; Peters, James E; Gilly, Arthur; Karaleftheri, Maria; Tsafantakis, Emmanouil; Haessler, Jeffrey; Gyllensten, Ulf; Harris, Sarah E; Wareham, Nicholas J; Göteson, Andreas; Lagging, Cecilia; Ikram, Mohammad Arfan; van Duijn, Cornelia M; Jern, Christina; Landén, Mikael; Langenberg, Claudia; Deary, Ian J; Marioni, Riccardo E; Enroth, Stefan; Reiner, Alexander P; Dedoussis, George; Zeggini, Eleftheria; Butterworth, Adam S; Mälarstig, Anders; Wilson, James F; Navarro, Pau; Shen, Xia.
Afiliación
  • Repetto L; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Chen J; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
  • Yang Z; Center for Intelligent Medicine Research, Greater Bay Area Institute of Precision Medicine (Guangzhou), Fudan University, Guangzhou, China.
  • Zhai R; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
  • Timmers PRHJ; Center for Intelligent Medicine Research, Greater Bay Area Institute of Precision Medicine (Guangzhou), Fudan University, Guangzhou, China.
  • Li T; Biostatistics Group, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
  • Twait EL; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
  • May-Wilson S; Center for Intelligent Medicine Research, Greater Bay Area Institute of Precision Medicine (Guangzhou), Fudan University, Guangzhou, China.
  • Muckian MD; Biostatistics Group, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
  • Prins BP; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
  • Png G; Center for Intelligent Medicine Research, Greater Bay Area Institute of Precision Medicine (Guangzhou), Fudan University, Guangzhou, China.
  • Kooperberg C; Biostatistics Group, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
  • Johansson Å; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Hillary RF; MRC Human Genetics Unit, MRC Institute of Genetics Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Wheeler E; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
  • Pan L; Center for Intelligent Medicine Research, Greater Bay Area Institute of Precision Medicine (Guangzhou), Fudan University, Guangzhou, China.
  • He Y; Biostatistics Group, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
  • Klasson S; Julius Center for Health Sciences and Primary Care, University Medical Center Utrechtand Utrecht University, Utrecht, Netherlands.
  • Ahmad S; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Peters JE; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Gilly A; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Karaleftheri M; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  • Tsafantakis E; Technical University of Munich (TUM), School of Medicine, 81675 Munich, Germany.
  • Haessler J; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle USA.
  • Gyllensten U; Dept. Immunology, Genetics and Pathology, Science for life laboratory, Uppsala University, Sweden.
  • Harris SE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, EH4 2XU, United Kingdom.
  • Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Göteson A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Lagging C; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Ikram MA; Institute of Biomedicine, Department of Laboratory Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • van Duijn CM; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.
  • Jern C; Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London, United Kingdom.
  • Landén M; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  • Langenberg C; Echinos Medical Centre, Echinos, Greece.
  • Deary IJ; Anogia Medical Centre, Anogia, Greece.
  • Marioni RE; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle USA.
  • Enroth S; Dept. Immunology, Genetics and Pathology, Science for life laboratory, Uppsala University, Sweden.
  • Reiner AP; Lothian Birth Cohorts, University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom.
  • Dedoussis G; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Zeggini E; Institute of Biomedicine, Department of Laboratory Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Butterworth AS; Institute of Biomedicine, Department of Laboratory Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Mälarstig A; Region Västra Götaland, Sahlgrenska University Hospital, Department of Clinical Genetics and Genomics, Gothenburg, Sweden.
  • Wilson JF; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.
  • Navarro P; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.
  • Shen X; Institute of Biomedicine, Department of Laboratory Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Res Sq ; 2023 Mar 31.
Article en En | MEDLINE | ID: mdl-37034613
ABSTRACT
Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioral traits and the disease etiology of neuropsychiatric disorders. Here, the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,500 individuals for 184 neuro-related proteins in human plasma. The analysis identified 117 cis-regulatory protein quantitative trait loci (cis-pQTL) and 166 trans-pQTL. The mapped pQTL capture on average 50% of each protein's heritability. Mendelian randomization analyses revealed multiple proteins showing potential causal effects on neuro-related traits such as sleeping, smoking, feelings, alcohol intake, mental health, and psychiatric disorders. Integrating with established drug information, we validated 13 out of 13 matched combinations of protein targets and diseases or side effects with available drugs, while suggesting hundreds of re-purposing and new therapeutic targets. This consortium effort provides a large-scale proteogenomic resource for biomedical research on human behaviors and other neuro-related phenotypes.
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Res Sq Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Res Sq Año: 2023 Tipo del documento: Article