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An optimized IL-12-Fc expands its therapeutic window, achieving strong activity against mouse tumors at tolerable drug doses.
Gutierrez, Eva; Bigelow, Mitchell; LaCroix, Colin; Beech, Jeremy; Kirby, Patrick; Markowitz, Lynn; Shifrin, Michael; Naill, Michael; Braun, Alexandra; O'Neil, Steve; Cuillerot, Jean-Marie; Cheung, Ann; Grinberg, Asya; Wagtmann, Nicolai.
Afiliación
  • Gutierrez E; Dragonfly Therapeutics, Waltham, MA 02451, USA. Electronic address: eva.gutierrez@dragonflytx.com.
  • Bigelow M; Dragonfly Therapeutics, Waltham, MA 02451, USA.
  • LaCroix C; Dragonfly Therapeutics, Waltham, MA 02451, USA.
  • Beech J; Dragonfly Therapeutics, Waltham, MA 02451, USA.
  • Kirby P; Dragonfly Therapeutics, Waltham, MA 02451, USA.
  • Markowitz L; Dragonfly Therapeutics, Waltham, MA 02451, USA.
  • Shifrin M; Dragonfly Therapeutics, Waltham, MA 02451, USA.
  • Naill M; Dragonfly Therapeutics, Waltham, MA 02451, USA.
  • Braun A; Dragonfly Therapeutics, Waltham, MA 02451, USA.
  • O'Neil S; Dragonfly Therapeutics, Waltham, MA 02451, USA.
  • Cuillerot JM; Dragonfly Therapeutics, Waltham, MA 02451, USA.
  • Cheung A; Dragonfly Therapeutics, Waltham, MA 02451, USA. Electronic address: ann.cheung@dragonflytx.com.
  • Grinberg A; Dragonfly Therapeutics, Waltham, MA 02451, USA.
  • Wagtmann N; Dragonfly Therapeutics, Waltham, MA 02451, USA.
Med ; 4(5): 326-340.e5, 2023 05 12.
Article en En | MEDLINE | ID: mdl-37059099

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Odonata / Neoplasias Idioma: En Revista: Med Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Odonata / Neoplasias Idioma: En Revista: Med Año: 2023 Tipo del documento: Article