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SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension.
Walters, Rachel; Vasilaki, Eleni; Aman, Jurjan; Chen, Chien-Nien; Wu, Yukyee; Liang, Olin D; Ashek, Ali; Dubois, Olivier; Zhao, Lin; Sabrin, Farah; Cebola, Inês; Ferrer, Jorge; Morrell, Nicholas W; Klinger, James R; Wilkins, Martin R; Zhao, Lan; Rhodes, Christopher J.
Afiliación
  • Walters R; National Heart and Lung Institute, Hammersmith Hospital, Imperial College, London, United Kingdom (R.W., E.V., J.A., C.-N.C., Y.W., A.A., O.D., L.Z., F.S., M.R.W., L.Z., C.J.R.).
  • Vasilaki E; National Heart and Lung Institute, Hammersmith Hospital, Imperial College, London, United Kingdom (R.W., E.V., J.A., C.-N.C., Y.W., A.A., O.D., L.Z., F.S., M.R.W., L.Z., C.J.R.).
  • Aman J; National Heart and Lung Institute, Hammersmith Hospital, Imperial College, London, United Kingdom (R.W., E.V., J.A., C.-N.C., Y.W., A.A., O.D., L.Z., F.S., M.R.W., L.Z., C.J.R.).
  • Chen CN; Department of Pulmonary Medicine, Amsterdam University Medical Center, The Netherlands (J.A.).
  • Wu Y; National Heart and Lung Institute, Hammersmith Hospital, Imperial College, London, United Kingdom (R.W., E.V., J.A., C.-N.C., Y.W., A.A., O.D., L.Z., F.S., M.R.W., L.Z., C.J.R.).
  • Liang OD; National Heart and Lung Institute, Hammersmith Hospital, Imperial College, London, United Kingdom (R.W., E.V., J.A., C.-N.C., Y.W., A.A., O.D., L.Z., F.S., M.R.W., L.Z., C.J.R.).
  • Ashek A; Division of Hematology/Oncology, Department of Medicine (O.D.L.), Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence.
  • Dubois O; National Heart and Lung Institute, Hammersmith Hospital, Imperial College, London, United Kingdom (R.W., E.V., J.A., C.-N.C., Y.W., A.A., O.D., L.Z., F.S., M.R.W., L.Z., C.J.R.).
  • Zhao L; National Heart and Lung Institute, Hammersmith Hospital, Imperial College, London, United Kingdom (R.W., E.V., J.A., C.-N.C., Y.W., A.A., O.D., L.Z., F.S., M.R.W., L.Z., C.J.R.).
  • Sabrin F; National Heart and Lung Institute, Hammersmith Hospital, Imperial College, London, United Kingdom (R.W., E.V., J.A., C.-N.C., Y.W., A.A., O.D., L.Z., F.S., M.R.W., L.Z., C.J.R.).
  • Cebola I; National Heart and Lung Institute, Hammersmith Hospital, Imperial College, London, United Kingdom (R.W., E.V., J.A., C.-N.C., Y.W., A.A., O.D., L.Z., F.S., M.R.W., L.Z., C.J.R.).
  • Ferrer J; Section of Genetics & Genomics, Department of Metabolism, Digestion & Reproduction, Hammersmith Hospital, Imperial College, London, United Kingdom (I.C., J.F.).
  • Morrell NW; Section of Genetics & Genomics, Department of Metabolism, Digestion & Reproduction, Hammersmith Hospital, Imperial College, London, United Kingdom (I.C., J.F.).
  • Klinger JR; Computational Biology and Health Genomics Programme, Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Spain (J.F.).
  • Wilkins MR; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Barcelona, Spain (J.F.).
  • Zhao L; Department of Medicine, University of Cambridge, United Kingdom (N.W.M.).
  • Rhodes CJ; NIHR BioResource for Translational Research, University of Cambridge, United Kingdom (N.W.M.).
Circulation ; 147(21): 1606-1621, 2023 05 23.
Article en En | MEDLINE | ID: mdl-37066790
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Hipertensión Arterial Pulmonar / Hipertensión Pulmonar Tipo de estudio: Prognostic_studies Idioma: En Revista: Circulation Año: 2023 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Hipertensión Arterial Pulmonar / Hipertensión Pulmonar Tipo de estudio: Prognostic_studies Idioma: En Revista: Circulation Año: 2023 Tipo del documento: Article