Molecular Networking Accelerated Discovery of Biflavonoid Alkaloids from Cephalotaxus sinensis.
Chem Biodivers
; 20(6): e202201197, 2023 Jun.
Article
en En
| MEDLINE
| ID: mdl-37073748
ABSTRACT
Four undescribed biflavonoid alkaloids, sinenbiflavones A-D, were isolated from Cephalotaxus sinensis using a MS/MS-based molecular networking guided strategy. Their structures were elucidated by series of spectroscopic methods (HR-ESI-MS, UV, IR, 1D, and 2D NMR). Sinenbiflavones A-D are the first examples of amentoflavone-type (C-3'-C-8'') biflavonoid alkaloids. Meanwhile, sinenbiflavones B and D are the unique C-6-methylated amentoflavone-type biflavonoid alkaloids. Sinenbiflavone D showed weak SARS-CoV-2 3CLpro inhibitory activity with 43 % inhibition rate at 40â
µM.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Cephalotaxus
/
Biflavonoides
/
Alcaloides
/
COVID-19
Idioma:
En
Revista:
Chem Biodivers
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2023
Tipo del documento:
Article