Lassa Virus Structural Biology and Replication.
Curr Top Microbiol Immunol
; 440: 147-164, 2023.
Article
en En
| MEDLINE
| ID: mdl-37100973
ABSTRACT
Lassa virus (LASV) is the causative agent of Lassa fever, an often-fatal hemorrhagic fever that is endemic in West Africa. LASV virions are enveloped and contain two single-stranded RNA genome segments. Both segments are ambisense and encode two proteins. The nucleoprotein associates with viral RNAs forming ribonucleoprotein complexes. The glycoprotein complex mediates viral attachment and entry. The Zinc protein serves as the matrix protein. Large is a polymerase that catalyzes viral RNA transcription and replication. LASV virion entry occurs via a clathrin-independent endocytic pathway usually involving alpha-dystroglycan and lysosomal associated membrane protein 1 as surface and intracellular receptors, respectively. Advances in understanding LASV structural biology and replication have facilitated development of promising vaccine and drug candidates.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Fiebre de Lassa
/
Virus Lassa
País/Región como asunto:
Africa
Idioma:
En
Revista:
Curr Top Microbiol Immunol
Año:
2023
Tipo del documento:
Article