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Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues.
Wagner, Viktoria; Kern, Fabian; Hahn, Oliver; Schaum, Nicholas; Ludwig, Nicole; Fehlmann, Tobias; Engel, Annika; Henn, Dominic; Rishik, Shusruto; Isakova, Alina; Tan, Michelle; Sit, Rene; Neff, Norma; Hart, Martin; Meese, Eckart; Quake, Steve; Wyss-Coray, Tony; Keller, Andreas.
Afiliación
  • Wagner V; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.
  • Kern F; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.
  • Hahn O; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Schaum N; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Saarland University Campus, Saarbrücken, Germany.
  • Ludwig N; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Fehlmann T; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
  • Engel A; Department of Human Genetics, Saarland University, Saarland, Germany.
  • Henn D; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.
  • Rishik S; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.
  • Isakova A; Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Tan M; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.
  • Sit R; Department of Bioengineering, Stanford University, Stanford, CA, USA.
  • Neff N; Department of Bioengineering, Stanford University, Stanford, CA, USA.
  • Hart M; Department of Bioengineering, Stanford University, Stanford, CA, USA.
  • Meese E; Department of Bioengineering, Stanford University, Stanford, CA, USA.
  • Quake S; Department of Human Genetics, Saarland University, Saarland, Germany.
  • Wyss-Coray T; Department of Human Genetics, Saarland University, Saarland, Germany.
  • Keller A; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Nat Biotechnol ; 42(1): 109-118, 2024 Jan.
Article en En | MEDLINE | ID: mdl-37106037
ABSTRACT
Molecular mechanisms of organismal and cell aging remain incompletely understood. We, therefore, generated a body-wide map of noncoding RNA (ncRNA) expression in aging (16 organs at ten timepoints from 1 to 27 months) and rejuvenated mice. We found molecular aging trajectories are largely tissue-specific except for eight broadly deregulated microRNAs (miRNAs). Their individual abundance mirrors their presence in circulating plasma and extracellular vesicles (EVs) whereas tissue-specific ncRNAs were less present. For miR-29c-3p, we observe the largest correlation with aging in solid organs, plasma and EVs. In mice rejuvenated by heterochronic parabiosis, miR-29c-3p was the most prominent miRNA restored to similar levels found in young liver. miR-29c-3p targets the extracellular matrix and secretion pathways, known to be implicated in aging. We provide a map of organism-wide expression of ncRNAs with aging and rejuvenation and identify a set of broadly deregulated miRNAs, which may function as systemic regulators of aging via plasma and EVs.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: MicroARNs Idioma: En Revista: Nat Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2024 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: MicroARNs Idioma: En Revista: Nat Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2024 Tipo del documento: Article