Non-Healing Corneal Ulcer and Uveitis Following Monkeypox Disease: Diagnostic and Therapeutic Challenges.
Ocul Immunol Inflamm
; 32(3): 253-258, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-37140328
ABSTRACT
PURPOSE:
The ocular manifestations of Monkeypox virus (Mpox) infection remain incompletely characterized. Our goal is to present a case series of non-healing corneal ulcers with associated uveitis caused by Mpox infection as well as management recommendations for Mpox-related ophthalmic disease (MPXROD).METHODS:
Retrospective case series.RESULTS:
Two male patients with recent hospitalization for systemic Mpox infection presented with non-healing corneal ulcer associated with anterior uveitis and severe IOP elevation. Despite initiation of conservative medical treatment including corticosteroid treatment for uveitis, in both cases, there was clinical progression with enlarging cornea lesions. Both cases received oral tecovirimat with complete healing of the corneal lesion.CONCLUSIONS:
Corneal ulcer and anterior uveitis are rare complications of Mpox infection. Although Mpox disease is generally anticipated to be self-limited, tecovirimat may be an effective intervention in poorly healing Mpox keratitis. Corticosteroids should be used with caution in Mpox uveitis, as they might lead to worsening infection.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Uveítis
/
Uveítis Anterior
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Úlcera de la Córnea
/
Enfermedades de la Córnea
/
Mpox
Tipo de estudio:
Diagnostic_studies
/
Guideline
Idioma:
En
Revista:
Ocul Immunol Inflamm
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
OFTALMOLOGIA
Año:
2024
Tipo del documento:
Article