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Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway.
Zhang, Junbing; Simpson, Claire M; Berner, Jacqueline; Chong, Harrison B; Fang, Jiafeng; Ordulu, Zehra; Weiss-Sadan, Tommy; Possemato, Anthony P; Harry, Stefan; Takahashi, Mariko; Yang, Tzu-Yi; Richter, Marianne; Patel, Himani; Smith, Abby E; Carlin, Alexander D; Hubertus de Groot, Adriaan F; Wolf, Konstantin; Shi, Lei; Wei, Ting-Yu; Dürr, Benedikt R; Chen, Nicholas J; Vornbäumen, Tristan; Wichmann, Nina O; Mahamdeh, Mohammed S; Pooladanda, Venkatesh; Matoba, Yusuke; Kumar, Shaan; Kim, Eugene; Bouberhan, Sara; Oliva, Esther; Rueda, Bo R; Soberman, Roy J; Bardeesy, Nabeel; Liau, Brian B; Lawrence, Michael; Stokes, Matt P; Beausoleil, Sean A; Bar-Peled, Liron.
Afiliación
  • Zhang J; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. Electronic address: jzhang75@mgh.harvard.edu.
  • Simpson CM; Cell Signaling Technology, Inc., Danvers, MA, USA.
  • Berner J; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Chong HB; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Fang J; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Ordulu Z; Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
  • Weiss-Sadan T; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Possemato AP; Cell Signaling Technology, Inc., Danvers, MA, USA.
  • Harry S; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Takahashi M; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Yang TY; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Richter M; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Patel H; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Smith AE; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Carlin AD; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Hubertus de Groot AF; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Wolf K; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Shi L; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Wei TY; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Dürr BR; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Chen NJ; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Vornbäumen T; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Wichmann NO; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Mahamdeh MS; Division of Cardiology, Harvard Medical School, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Pooladanda V; Department of Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA; Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA.
  • Matoba Y; Department of Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA; Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA.
  • Kumar S; Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA.
  • Kim E; Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA.
  • Bouberhan S; Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Oliva E; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
  • Rueda BR; Department of Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA; Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA.
  • Soberman RJ; Division of Nephrology, Harvard Medical School, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Bardeesy N; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Liau BB; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
  • Lawrence M; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Stokes MP; Cell Signaling Technology, Inc., Danvers, MA, USA.
  • Beausoleil SA; Cell Signaling Technology, Inc., Danvers, MA, USA.
  • Bar-Peled L; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: lbar-peled@mgh.harvard.edu.
Cell ; 186(11): 2361-2379.e25, 2023 05 25.
Article en En | MEDLINE | ID: mdl-37192619
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Especies Reactivas de Oxígeno / Antineoplásicos Tipo de estudio: Diagnostic_studies Idioma: En Revista: Cell Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Especies Reactivas de Oxígeno / Antineoplásicos Tipo de estudio: Diagnostic_studies Idioma: En Revista: Cell Año: 2023 Tipo del documento: Article