Ionic displacement of Ca<sup>2+</sup> by Pb<sup>2+</sup> in calmodulin is affected by arrhythmia-associated mutations.

Marino, Valerio; Dal Cortivo, Giuditta; Dell'Orco, Daniele

Ionic displacement of Ca²⁺ by Pb²⁺ in calmodulin is affected by arrhythmia-associated mutations.

Marino, Valerio; Dal Cortivo, Giuditta; Dell'Orco, Daniele.

Afiliación

Marino V; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, I-37134 Verona, Italy.
Dal Cortivo G; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, I-37134 Verona, Italy.
Dell'Orco D; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, I-37134 Verona, Italy. Electronic address: daniele.dellorco@univr.it.

Biochim Biophys Acta Mol Cell Res ; 1870(6): 119490, 2023 08.

Article en En | MEDLINE | ID: mdl-37201768

Asunto(s)

Calmodulina; Plomo; Humanos; Calmodulina/metabolismo; Canal Liberador de Calcio Receptor de Rianodina/metabolismo; Arritmias Cardíacas/genética; Mutación

Palabras clave

Arrhythmia; Ca(2+)-sensor; Calmodulin; Circular dichroism; Heavy metals; Ionic displacement; Lead; Molecular dynamics; Ryanodine receptors

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Calmodulina / Plomo Tipo de estudio: Risk_factors_studies Idioma: En Revista: Biochim Biophys Acta Mol Cell Res Año: 2023 Tipo del documento: Article

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