Modeling Meningiomas: Optimizing Treatment Approach.
Neurosurg Clin N Am
; 34(3): 479-492, 2023 Jul.
Article
en En
| MEDLINE
| ID: mdl-37210136
ABSTRACT
Preclinical meningioma models offer a setting to test molecular mechanisms of tumor development and targeted treatment options but historically have been challenging to generate. Few spontaneous tumor models in rodents have been established, but cell culture and in vivo rodent models have emerged along with artificial intelligence, radiomics, and neural networks to differentiate the clinical heterogeneity of meningiomas. We reviewed 127 studies using PRISMA guideline methodology, including laboratory and animal studies, that addressed preclinical modeling. Our evaluation identified that meningioma preclinical models provide valuable molecular insight into disease progression and effective chemotherapeutic and radiation approaches for specific tumor types.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Meníngeas
/
Meningioma
Tipo de estudio:
Guideline
/
Prognostic_studies
Idioma:
En
Revista:
Neurosurg Clin N Am
Asunto de la revista:
NEUROCIRURGIA
Año:
2023
Tipo del documento:
Article