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A pilot study of closed-loop neuromodulation for treatment-resistant post-traumatic stress disorder.
Gill, Jay L; Schneiders, Julia A; Stangl, Matthias; Aghajan, Zahra M; Vallejo, Mauricio; Hiller, Sonja; Topalovic, Uros; Inman, Cory S; Villaroman, Diane; Bari, Ausaf; Adhikari, Avishek; Rao, Vikram R; Fanselow, Michael S; Craske, Michelle G; Krahl, Scott E; Chen, James W Y; Vick, Merit; Hasulak, Nicholas R; Kao, Jonathan C; Koek, Ralph J; Suthana, Nanthia; Langevin, Jean-Philippe.
Afiliación
  • Gill JL; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
  • Schneiders JA; Medical Scientist Training Program, University of California, Los Angeles, CA, USA.
  • Stangl M; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
  • Aghajan ZM; Research and Development Service; Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
  • Vallejo M; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
  • Hiller S; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
  • Topalovic U; Department of Neurosurgery, University of California, Los Angeles, CA, USA.
  • Inman CS; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
  • Villaroman D; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
  • Bari A; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
  • Adhikari A; Department of Electrical and Computer Engineering, University of California, Los Angeles, CA, USA.
  • Rao VR; Department of Psychology, University of Utah, Salt Lake City, UT, USA.
  • Fanselow MS; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
  • Craske MG; Department of Neurosurgery, University of California, Los Angeles, CA, USA.
  • Krahl SE; Department of Psychology, University of California, Los Angeles, CA, USA.
  • Chen JWY; Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
  • Vick M; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
  • Hasulak NR; Department of Psychology, University of California, Los Angeles, CA, USA.
  • Kao JC; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
  • Koek RJ; Department of Psychology, University of California, Los Angeles, CA, USA.
  • Suthana N; Research and Development Service; Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
  • Langevin JP; Department of Neurosurgery, University of California, Los Angeles, CA, USA.
Nat Commun ; 14(1): 2997, 2023 05 24.
Article en En | MEDLINE | ID: mdl-37225710
ABSTRACT
The neurophysiological mechanisms in the human amygdala that underlie post-traumatic stress disorder (PTSD) remain poorly understood. In a first-of-its-kind pilot study, we recorded intracranial electroencephalographic data longitudinally (over one year) in two male individuals with amygdala electrodes implanted for the management of treatment-resistant PTSD (TR-PTSD) under clinical trial NCT04152993. To determine electrophysiological signatures related to emotionally aversive and clinically relevant states (trial primary endpoint), we characterized neural activity during unpleasant portions of three separate paradigms (negative emotional image viewing, listening to recordings of participant-specific trauma-related memories, and at-home-periods of symptom exacerbation). We found selective increases in amygdala theta (5-9 Hz) bandpower across all three negative experiences. Subsequent use of elevations in low-frequency amygdala bandpower as a trigger for closed-loop neuromodulation led to significant reductions in TR-PTSD symptoms (trial secondary endpoint) following one year of treatment as well as reductions in aversive-related amygdala theta activity. Altogether, our findings provide early evidence that elevated amygdala theta activity across a range of negative-related behavioral states may be a promising target for future closed-loop neuromodulation therapies in PTSD.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Gastrópodos Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Gastrópodos Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article