Metagenome-mining indicates an association between bacteriocin presence and strain diversity in the infant gut.
BMC Genomics
; 24(1): 295, 2023 May 31.
Article
en En
| MEDLINE
| ID: mdl-37259063
ABSTRACT
BACKGROUND:
Our knowledge about the ecological role of bacterial antimicrobial peptides (bacteriocins) in the human gut is limited, particularly in relation to their role in the diversification of the gut microbiota during early life. The aim of this paper was therefore to address associations between bacteriocins and bacterial diversity in the human gut microbiota. To investigate this, we did an extensive screening of 2564 healthy human gut metagenomes for the presence of predicted bacteriocin-encoding genes, comparing bacteriocin gene presence to strain diversity and age.RESULTS:
We found that the abundance of bacteriocin genes was significantly higher in infant-like metagenomes (< 2 years) compared to adult-like metagenomes (2-107 years). By comparing infant-like metagenomes with and without a given bacteriocin, we found that bacteriocin presence was associated with increased strain diversities.CONCLUSIONS:
Our findings indicate that bacteriocins may play a role in the strain diversification during the infant gut microbiota establishment.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Metagenoma
/
Microbioma Gastrointestinal
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
BMC Genomics
Asunto de la revista:
GENETICA
Año:
2023
Tipo del documento:
Article