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Recurrence patterns among patients with sinonasal mucosal melanoma: A multi-institutional study.
Pandrangi, Vivek C; Mace, Jess C; Abiri, Arash; Adappa, Nithin D; Beswick, Daniel M; Chang, Eugene H; Eide, Jacob G; Fung, Nicholas; Hong, Michelle; Johnson, Brian J; Kohanski, Michael A; Kshirsagar, Rijul S; Kuan, Edward C; Le, Christopher H; Lee, Jivianne T; Nabavizadeh, Seyed A; Obermeyer, Isaac P; Palmer, James N; Pinheiro-Neto, Carlos D; Smith, Timothy L; Snyderman, Carl H; Suh, Jeffrey D; Wang, Eric W; Wang, Marilene B; Choby, Garret; Geltzeiler, Mathew.
Afiliación
  • Pandrangi VC; Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.
  • Mace JC; Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.
  • Abiri A; Department of Otolaryngology-Head and Neck Surgery, University of California Irvine, Orange, California, USA.
  • Adappa ND; Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Beswick DM; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Chang EH; Department of Otolaryngology-Head and Neck Surgery, University of Arizona, Tucson, Arizona, USA.
  • Eide JG; Department of Otolaryngology-Head and Neck Surgery, Henry Ford Health System, Detroit, Michigan, USA.
  • Fung N; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Hong M; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Johnson BJ; Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.
  • Kohanski MA; Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Kshirsagar RS; Department of Otolaryngology-Head and Neck Surgery, Kaiser Permanente Redwood City Medical Center, Redwood City, California, USA.
  • Kuan EC; Department of Otolaryngology-Head and Neck Surgery, University of California Irvine, Orange, California, USA.
  • Le CH; Department of Otolaryngology-Head and Neck Surgery, University of Arizona, Tucson, Arizona, USA.
  • Lee JT; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Nabavizadeh SA; Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Obermeyer IP; Department of Otolaryngology-Head and Neck Surgery, University of California Irvine, Orange, California, USA.
  • Palmer JN; Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Pinheiro-Neto CD; Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.
  • Smith TL; Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.
  • Snyderman CH; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Suh JD; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Wang EW; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Wang MB; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Choby G; Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.
  • Geltzeiler M; Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.
Int Forum Allergy Rhinol ; 13(12): 2156-2164, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37265013
ABSTRACT

OBJECTIVE:

To evaluate recurrence patterns and survival after recurrence among patients with sinonasal mucosal melanoma (SNMM).

METHODS:

This was a multi-institutional retrospective review from seven U.S. institutions of patients with SNMM from 1991 to 2022. Recurrence was categorized as local, regional, distant, or multifocal. Kaplan-Meier tests were used to evaluate disease-free survival (DFS), overall survival (OS), and post-recurrence survival (PRS) reported with standard errors (SE) and log-rank testing used for comparison. Cox-regression was further used, with hazard ratios (HR) and 95% confidence intervals (CI) reported.

RESULTS:

Among 196 patients with SNMM, there were 146 patients with recurrence (74.5%). Among all patients, 60-month DFS (SE) was 15.5% (2.9%), 60-month OS (SE) was 44.7% (3.7%), mean age ± standard deviation at diagnosis was 69.7 ± 12.5 years, and 54.6% were female. In 26 patients who underwent primary treatment of the neck, 60-month DFS did not differ from no treatment (p > 0.05). Isolated distant recurrence was most common (42.8%), followed by local (28.3%), multifocal (20.7%), and regional recurrence (8.3%). Among patients with regional recurrence in the neck, there was no 60-month PRS benefit for patients undergoing salvage neck dissection or radiation (p > 0.05). Among patients with distant recurrence, only immunotherapy was associated with improved 12-month PRS (HR = 0.32, 95% CI = 0.11-0.92, p = 0.034), and no treatment group was associated with improved 24- or 60-month PRS (p > 0.05).

CONCLUSION:

SNMM is associated with a high recurrence rate and poor survival. Primary treatment of the neck was not associated with reduced recurrence, and immunotherapy for treatment of distant recurrence was associated with increased 12-month PRS.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias de los Senos Paranasales / Melanoma Idioma: En Revista: Int Forum Allergy Rhinol Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias de los Senos Paranasales / Melanoma Idioma: En Revista: Int Forum Allergy Rhinol Año: 2023 Tipo del documento: Article