Iron-Catalyzed Oxidative Cyclization of 2-Amino Styrenes with Alcohols and Methyl Arenes for the Synthesis of Polysubstituted Quinolines.
J Org Chem
; 88(13): 8099-8113, 2023 Jul 07.
Article
en En
| MEDLINE
| ID: mdl-37285286
ABSTRACT
Herein, we present the iron-catalyzed oxidative cyclization of alcohol/methyl arene with 2-amino styrene to synthesize polysubstituted quinoline. Low-oxidation level substrates such as alcohols and methyl arenes are converted to aldehydes in the presence of an iron catalyst and di-t-butyl peroxide. Then, the quinoline scaffold is synthesized through imine condensation/radical cyclization/oxidative aromatization. Our protocol showed a broad substrate scope, and various functionalization and fluorescence applications of quinoline products demonstrated its synthetic ability.
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1
Base de datos:
MEDLINE
Asunto principal:
Quinolinas
/
Estirenos
Idioma:
En
Revista:
J Org Chem
Año:
2023
Tipo del documento:
Article