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SLC35E1 promotes keratinocyte proliferation in psoriasis by regulating zinc homeostasis.
Huang, Tao; Chen, Shijun; Ding, Ke; Zheng, Baoqing; Lv, Weiqi; Wang, Xiaobo; Zhong, Yadan; Huang, Hongxin; Zhang, Xin; Ma, Shufeng; Yang, Bin; Wang, Xiaohua; Rong, Zhili.
Afiliación
  • Huang T; Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, 510515, China.
  • Chen S; Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.
  • Ding K; Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, 510515, China.
  • Zheng B; Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, 510515, China.
  • Lv W; Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.
  • Wang X; Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.
  • Zhong Y; Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.
  • Huang H; Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.
  • Zhang X; Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.
  • Ma S; Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.
  • Yang B; Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, 510515, China.
  • Wang X; Affiliated Dongguan Hospital, Southern Medical University, (Dongguan People's Hospital), Dongguan, 523058, China.
  • Rong Z; Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, 510515, China.
Cell Death Dis ; 14(6): 354, 2023 06 09.
Article en En | MEDLINE | ID: mdl-37296095
Keratinocyte hyperproliferation is a key pathogenic factor in psoriasis. However, the mechanisms that regulate keratinocyte hyperproliferation in this condition remain unclear. Here, we found that SLC35E1 was highly expressed in keratinocytes of patients with psoriasis and that Slc35e1-/- mice displayed a less severe imiquimod (IMQ)-induced psoriasis-like phenotype than their wild-type siblings. In addition, SLC35E1 deficiency inhibited keratinocyte proliferation in both mice and cultured cells. On a molecular level, SLC35E1 was found to regulate zinc ion concentrations and subcellular localization, while zinc ion chelation reversed the IMQ-induced psoriatic phenotype in Slc35e1-/- mice. Meanwhile, epidermal zinc ion levels were decreased in patients with psoriasis and zinc ion supplementation alleviated the psoriatic phenotype in an IMQ-induced mouse model of psoriasis. Our results indicated that SLC35E1 can promote keratinocyte proliferation by regulating zinc ion homeostasis and zinc ion supplementation has potential as a therapy for psoriasis.
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Psoriasis Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Death Dis Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Psoriasis Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Death Dis Año: 2023 Tipo del documento: Article