Curcumin protects against the age-related hearing loss by attenuating apoptosis and senescence via activating Nrf2 signaling in cochlear hair cells.

Li, Ning; Yan, Xirui; Huang, Weiling; Chu, Min; Dong, Yang; Song, Haiyan; Peng, Yinting; Shi, Jianrong; Liu, Qing

Li, Ning; Yan, Xirui; Huang, Weiling; Chu, Min; Dong, Yang; Song, Haiyan; Peng, Yinting; Shi, Jianrong; Liu, Qing.

Afiliación

Li N; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yan X; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Huang W; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chu M; Experimental Teaching Center, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Dong Y; Experimental Teaching Center, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Song H; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Peng Y; Experimental Teaching Center, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shi J; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Liu Q; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: qingliu@shutcm.edu.cn.

Biochem Pharmacol ; 212: 115575, 2023 06.

Article en En | MEDLINE | ID: mdl-37334787

Asunto(s)

Curcumina; Pérdida Auditiva; Enfermedades Neurodegenerativas; Anciano; Ratones; Animales; Humanos; Factor 2 Relacionado con NF-E2/genética; Factor 2 Relacionado con NF-E2/metabolismo; Especies Reactivas de Oxígeno/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Curcumina/farmacología; Curcumina/uso terapéutico; Peróxido de Hidrógeno/farmacología; Ratones Endogámicos C57BL; Pérdida Auditiva/prevención & control; Apoptosis; Células Ciliadas Auditivas/metabolismo

Palabras clave

AKT; Age-related hearing loss; Cochlear; Curcumin; Nrf2; Oxidative stress

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Curcumina / Pérdida Auditiva Tipo de estudio: Prognostic_studies Idioma: En Revista: Biochem Pharmacol Año: 2023 Tipo del documento: Article

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