Hybrid liquid chromatography high resolution and accuracy mass spectrometry approach for quantification of antibody-drug conjugates at the intact protein level in biological samples.

Barbero, Luca M; Ianni, Andrea Di; Molinaro, Francesco; Cowan, Kyra J; Sirtori, Federico Riccardi

Barbero, Luca M; Ianni, Andrea Di; Molinaro, Francesco; Cowan, Kyra J; Sirtori, Federico Riccardi.

Afiliación

Barbero LM; NBE-DMPK Innovative BioAnalytics, Merck Serono RBM S.P.A., An Affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, Colleretto Giacosa (TO) 10010, Italy. Electronic address: luca.barbero@merckgroup.com.
Ianni AD; NBE-DMPK Innovative BioAnalytics, Merck Serono RBM S.P.A., An Affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, Colleretto Giacosa (TO) 10010, Italy; Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.
Molinaro F; NBE-DMPK Innovative BioAnalytics, Merck Serono RBM S.P.A., An Affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, Colleretto Giacosa (TO) 10010, Italy.
Cowan KJ; NBE-DMPK Innovative BioAnalytics, Merck Serono RBM S.P.A., An Affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, Colleretto Giacosa (TO) 10010, Italy.
Sirtori FR; NBE-DMPK Innovative BioAnalytics, Merck Serono RBM S.P.A., An Affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, Colleretto Giacosa (TO) 10010, Italy.

Eur J Pharm Sci ; 188: 106502, 2023 Sep 01.

Article en En | MEDLINE | ID: mdl-37336420

Palabras clave

ADC; Bioanalysis; Hybrid method; LC-MS; Quantitation of large molecules

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Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Qualitative_research Idioma: En Revista: Eur J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2023 Tipo del documento: Article

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