Facile preparation of biocompatible and antibacterial water-soluble films using polyvinyl alcohol/carboxymethyl chitosan blend fibers via centrifugal spinning.

Water-soluble polyvinyl alcohol/carboxymethyl chitosan (PVA/CMCS) blend fiber films were successfully prepared using a plane-collection centrifugal spinning machine. The addition of CMCS significantly increased the shear viscosity of the PVA/CMCS blend solution. The effects of spinning temperature on the shear viscosity and the centrifugal spinnability of PVA/CMCS blend solution were discussed. The PVA/CMCS blend fibers were uniform, and their average diameters ranged from 1.23 µm to 29.01 µm. It was found that the CMCS was distributed evenly in the PVA matrix and increased the crystallinity of PVA/CMCS blend fiber films. The hydrogen bonds between the hydroxyl group of PVA and the carboxymethyl group of CMCS were also detected. An in vitro cell study of human skin fibroblast cells on the PVA/CMCS blend fiber films confirmed biocompatibility. The maximum tensile strength and elongation at break of PVA/CMCS blend fiber films could reach 3.28 MPa and 29.52 %, respectively. The colony-plate-count tests indicated that the PVA16-CMCS2 presented 72.05 % and 21.36 % antibacterial rates against Staphylococcus aureus (104 CFU/mL) and Escherichia coli (103 CFU/mL), respectively. These values indicated that the newly prepared PVA/CMCS blend fiber films are promising materials for cosmetic and dermatological applications.