Cutaneous changes in diabetic patients: Primed for aberrant healing?
Wound Repair Regen
; 31(5): 700-712, 2023.
Article
en En
| MEDLINE
| ID: mdl-37365017
ABSTRACT
Cutaneous manifestations affect most patients with diabetes mellitus, clinically presenting with numerous dermatologic diseases from xerosis to diabetic foot ulcers (DFUs). Skin conditions not only impose a significantly impaired quality of life on individuals with diabetes but also predispose patients to further complications. Knowledge of cutaneous biology and the wound healing process under diabetic conditions is largely limited to animal models, and studies focusing on biology of the human condition of DFUs remain limited. In this review, we discuss the critical molecular, cellular, and structural changes to the skin in the hyperglycaemic and insulin-resistant environment of diabetes with a focus specifically on human-derived data. Elucidating the breadth of the cutaneous manifestations coupled with effective diabetes management is important for improving patient quality of life and averting future complications including wound healing disorders.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Pie Diabético
/
Diabetes Mellitus
Idioma:
En
Revista:
Wound Repair Regen
Asunto de la revista:
DERMATOLOGIA
Año:
2023
Tipo del documento:
Article