Cross-linking disulfide bonds govern solution structures of diabodies.

Math, Barbara A; Waibl, Franz; Lamp, Leonida M; Fernández-Quintero, Monica L; Liedl, Klaus R

Math, Barbara A; Waibl, Franz; Lamp, Leonida M; Fernández-Quintero, Monica L; Liedl, Klaus R.

Afiliación

Math BA; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria.
Waibl F; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria.
Lamp LM; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria.
Fernández-Quintero ML; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria.
Liedl KR; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria.

Proteins ; 91(9): 1316-1328, 2023 09.

Article en En | MEDLINE | ID: mdl-37376973

Asunto(s)

Anticuerpos; Fragmentos Fab de Inmunoglobulinas; Conformación Proteica; Sitios de Unión de Anticuerpos; Fragmentos Fab de Inmunoglobulinas/química; Disulfuros

Palabras clave

diabodies; enhanced sampling; interdomain orientation dynamics; molecular dynamics simulations; novel antibody formats

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fragmentos Fab de Inmunoglobulinas / Anticuerpos Idioma: En Revista: Proteins Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article

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