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The complexity of genitourinary syndrome of menopause: number, severity, and frequency of vulvovaginal discomfort symptoms in women enrolled in a randomized trial evaluating treatment for genitourinary syndrome of menopause.
Mitchell, Caroline M; Larson, Joseph C; Reed, Susan D; Guthrie, Katherine A.
Afiliación
  • Mitchell CM; From the Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA.
  • Larson JC; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA.
  • Guthrie KA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA.
Menopause ; 30(8): 791-797, 2023 08 01.
Article en En | MEDLINE | ID: mdl-37402281
OBJECTIVE: The aim of the study is to describe the location, severity, and frequency of genitourinary symptoms in postmenopausal women enrolled in a randomized trial of treatment for vulvovaginal discomfort. METHODS: This is a post hoc analysis of enrollment responses for participants in the MsFLASH Vaginal Health Trial. Participants were asked about the severity (0-3), frequency (in days per week) and location (vulvar or vaginal) of itch, dryness, pain/soreness, irritation, as well as severity and frequency of pain with penetration, vaginal discharge, urinary incontinence, and urinary urgency. RESULTS: A total of 302 participants were enrolled, with a mean age of 60.9 ± 4.1 years. The mean number of moderate-severe vulvovaginal symptoms experienced by trial participants in the month before enrollment was 3.4 ± 1.5, with a range from 1 to 7. The most commonly reported symptom across all severity categories was vaginal dryness (285/302, 94%), but the one most frequently rated as severe was pain with vaginal penetration (121/302, 40%). Vaginal dryness was the symptom with highest frequency; 53% of participants with that symptom reported experiencing it ≥4 d/wk. For vaginal symptoms, 80% of participants (241/302) reported that at least one of these symptoms occurred during or after sex while only 43% (158/302) reported that at least one vulvar symptom occurred during or after sex. Urinary incontinence (202/302, 67%) and urinary frequency (128/302, 43%) were the two most commonly reported urinary issues. CONCLUSIONS: Our data highlight the complexity of genitourinary syndrome of menopause symptoms in quantity, severity, and frequency, suggesting that measuring distress, bother, or interference may be the most comprehensive measure.
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Incontinencia Urinaria / Enfermedades Vaginales Tipo de estudio: Clinical_trials / Diagnostic_studies Idioma: En Revista: Menopause Asunto de la revista: GINECOLOGIA Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Incontinencia Urinaria / Enfermedades Vaginales Tipo de estudio: Clinical_trials / Diagnostic_studies Idioma: En Revista: Menopause Asunto de la revista: GINECOLOGIA Año: 2023 Tipo del documento: Article