Your browser doesn't support javascript.
loading
Detection of Early Diffuse Myocardial Fibrosis and Inflammation in Chagas Cardiomyopathy with T1 Mapping and Extracellular Volume.
Melo, Rodrigo J L; Assunção, Antonildes N; Morais, Thamara C; Nomura, Cesar H; Scanavacca, Mauricio I; Martinelli-Filho, Martino; Ramires, Felix J A; Fernandes, Fabio; Ianni, Barbara M; Mady, Charles; Rochitte, Carlos E.
Afiliación
  • Melo RJL; From the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of
  • Assunção AN; From the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of
  • Morais TC; From the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of
  • Nomura CH; From the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of
  • Scanavacca MI; From the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of
  • Martinelli-Filho M; From the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of
  • Ramires FJA; From the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of
  • Fernandes F; From the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of
  • Ianni BM; From the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of
  • Mady C; From the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of
  • Rochitte CE; From the Cardiovascular Magnetic Resonance and Computed Tomography Sector (R.J.L.M., A.N.A., T.C.M., C.H.N., C.E.R.), Arrhythmia Unit (M.I.S.), Artificial Cardiac Stimulation Unit (M.M.F.), and Cardiomyopathy Unit (F.J.A.R., F.F., B.M.I., C.M.), Heart Institute (Instituto do Coração), University of
Radiol Cardiothorac Imaging ; 5(3): e220112, 2023 Jun.
Article en En | MEDLINE | ID: mdl-37404789
Purpose: To evaluate myocardial T1 mapping and extracellular volume (ECV) parameters in different stages of Chagas cardiomyopathy and determine whether they are predictive of disease severity and prognosis. Materials and Methods: Prospectively enrolled participants (July 2013 to September 2016) underwent cine and late gadolinium enhancement (LGE) cardiac MRI and T1 mapping with a precontrast (native) or postcontrast modified Look-Locker sequence. The native T1 and ECV values were measured among subgroups that were based on disease severity (indeterminate, Chagas cardiomyopathy with preserved ejection fraction [CCpEF], Chagas cardiomyopathy with midrange ejection fraction [CCmrEF], and Chagas cardiomyopathy with reduced ejection fraction [CCrEF]). Cox proportional hazards regression and the Akaike information criterion were used to determine predictors of major cardiovascular events (cardioverter defibrillator implant, heart transplant, or death). Results: In 107 participants (90 participants with Chagas disease [mean age ± SD, 55 years ± 11; 49 men] and 17 age- and sex-matched control participants), the left ventricular (LV) ejection fraction and the extent of focal and diffuse or interstitial fibrosis were correlated with disease severity. Participants with CCmrEF and participants with CCrEF showed significantly higher global native T1 and ECV values than participants in the indeterminate, CCpEF, and control groups (T1: 1072 msec ± 34 and 1073 msec ± 63 vs 1010 msec ± 41, 1005 msec ± 69, and 999 msec ± 46; ECV: 35.5% ± 3.6 and 35.0% ± 5.4 vs 25.3% ± 3.5, 28.2% ± 4.9, and 25.2% ± 2.2; both P < .001). Remote (LGE-negative areas) native T1 and ECV values were also higher (T1: 1056 msec ± 32 and 1071 msec ± 55 vs 1008 msec ± 41, 989 msec ± 96, and 999 msec ± 46; ECV: 30.2% ± 4.7 and 30.8% ± 7.4 vs 25.1% ± 3.5, 25.1% ± 3.7, and 25.0% ± 2.2; both P < .001). Abnormal remote ECV values (>30%) occurred in 12% of participants in the indeterminate group, which increased with disease severity. Nineteen combined outcomes were observed (median follow-up time: 43 months), and a remote native T1 value greater than 1100 msec was independently predictive of combined outcomes (hazard ratio, 12 [95% CI: 4.1, 34.2]; P < .001). Conclusion: Myocardial native T1 and ECV values were correlated with Chagas disease severity and may serve as markers of myocardial involvement in Chagas cardiomyopathy that precede LGE and LV dysfunction.Keywords: MRI, Cardiac, Heart, Imaging Sequences, Chagas Cardiomyopathy Supplemental material is available for this article. © RSNA, 2023.
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Radiol Cardiothorac Imaging Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Radiol Cardiothorac Imaging Año: 2023 Tipo del documento: Article