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Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses.
Sulczewski, Fernando Bandeira; Maqueda-Alfaro, Raul A; Alcántara-Hernández, Marcela; Perez, Oriana A; Saravanan, Sanjana; Yun, Tae Jin; Seong, David; Arroyo Hornero, Rebeca; Raquer-McKay, Hayley M; Esteva, Eduardo; Lanzar, Zachary R; Leylek, Rebecca A; Adams, Nicholas M; Das, Annesa; Rahman, Adeeb H; Gottfried-Blackmore, Andres; Reizis, Boris; Idoyaga, Juliana.
Afiliación
  • Sulczewski FB; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
  • Maqueda-Alfaro RA; Immunology Program, Stanford University School of Medicine, Stanford, CA, USA.
  • Alcántara-Hernández M; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
  • Perez OA; Immunology Program, Stanford University School of Medicine, Stanford, CA, USA.
  • Saravanan S; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
  • Yun TJ; Immunology Program, Stanford University School of Medicine, Stanford, CA, USA.
  • Seong D; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
  • Arroyo Hornero R; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
  • Raquer-McKay HM; Immunology Program, Stanford University School of Medicine, Stanford, CA, USA.
  • Esteva E; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
  • Lanzar ZR; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
  • Leylek RA; Immunology Program, Stanford University School of Medicine, Stanford, CA, USA.
  • Adams NM; Medical Scientist Training Program, Stanford University School of Medicine, Stanford, CA, USA.
  • Das A; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
  • Rahman AH; Immunology Program, Stanford University School of Medicine, Stanford, CA, USA.
  • Gottfried-Blackmore A; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
  • Reizis B; Immunology Program, Stanford University School of Medicine, Stanford, CA, USA.
  • Idoyaga J; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Nat Immunol ; 24(8): 1265-1280, 2023 08.
Article en En | MEDLINE | ID: mdl-37414907
High-dimensional approaches have revealed heterogeneity amongst dendritic cells (DCs), including a population of transitional DCs (tDCs) in mice and humans. However, the origin and relationship of tDCs to other DC subsets has been unclear. Here we show that tDCs are distinct from other well-characterized DCs and conventional DC precursors (pre-cDCs). We demonstrate that tDCs originate from bone marrow progenitors shared with plasmacytoid DCs (pDCs). In the periphery, tDCs contribute to the pool of ESAM+ type 2 DCs (DC2s), and these DC2s have pDC-related developmental features. Different from pre-cDCs, tDCs have less turnover, capture antigen, respond to stimuli and activate antigen-specific naïve T cells, all characteristics of differentiated DCs. Different from pDCs, viral sensing by tDCs results in IL-1ß secretion and fatal immune pathology in a murine coronavirus model. Our findings suggest that tDCs are a distinct pDC-related subset with a DC2 differentiation potential and unique proinflammatory function during viral infections.
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Médula Ósea / Células Dendríticas Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Médula Ósea / Células Dendríticas Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article