Copper-catalyzed tandem cyclization/arylation of α,ß-alkynic hydrazones with diaryliodonium salts: synthesis of N-arylpyrazoles.
Org Biomol Chem
; 21(28): 5784-5789, 2023 Jul 19.
Article
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| MEDLINE
| ID: mdl-37424496
ABSTRACT
A copper-catalyzed efficient method for the synthesis of a diverse variety of substituted N-aryl pyrazoles from readily available α,ß-alkynic N-tosyl hydrazones and diaryliodonium triflates is realized. This one-pot multi-step methodology features a broad scope with good yields, scalability, and appreciable functional group tolerance. Detailed control experiments reveal that the reaction proceeds through tandem cyclization/deprotection/arylation events where the copper catalyst plays a distinct role.
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MEDLINE
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En
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Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2023
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Article