PC4-mediated Ku complex PARylation facilitates NHEJ-dependent DNA damage repair.

Pan, Qimei; Luo, Peng; Shi, Chunmeng

Pan, Qimei; Luo, Peng; Shi, Chunmeng.

Afiliación

Pan Q; State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Rocket Force Medicine, Third Military Medical University (Army Medical University), Chongqing, China.
Luo P; State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Rocket Force Medicine, Third Military Medical University (Army Medical University), Chongqing, China.
Shi C; State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Rocket Force Medicine, Third Military Medical University (Army Medical University), Chongqing, China. Electronic address: shicm@tmmu.edu.cn.

J Biol Chem ; 299(8): 105032, 2023 08.

Article en En | MEDLINE | ID: mdl-37437887

Asunto(s)

Carcinoma Hepatocelular; Neoplasias Hepáticas; Humanos; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/radioterapia; Daño del ADN; Reparación del ADN por Unión de Extremidades; Reparación del ADN; Autoantígeno Ku/genética; Autoantígeno Ku/metabolismo; Neoplasias Hepáticas/genética; Recurrencia Local de Neoplasia; Poli ADP Ribosilación; Tolerancia a Radiación

Palabras clave

DNA damage repair; KU; PARP1; PARylation; hepatocellular carcinoma; nonhomologous end joining; positive cofactor 4

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article

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