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Tetrahedral Framework Nucleic Acids Inhibit Muscular Mitochondria-Mediated Apoptosis and Ameliorate Muscle Atrophy in Sarcopenia.
Yu, Xi; Wang, Yun; Ran, Liyu; Jiang, Yang; Chen, Ming; Du, Hao; Zhang, Yao; Wu, Diwei; Xiang, Xiaona; Zhang, Jiawei; Jiang, Ning; He, Hongchen; Song, Yueming; Xiang, Zhou; He, Chengqi; Zhou, Zongke; Zeng, Jiancheng; Xiang, Yong; Huang, Shi-Shu; Lin, Yunfeng.
Afiliación
  • Yu X; Department of Orthopedic Surgery and Orthopedic Research Institute, Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • Wang Y; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • Ran L; Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • Jiang Y; The Second Affiliated Hospital of Chengdu Medical College, 416 Nuclear Industry Hospital, Chengdu 610057, Sichuan, People's Republic of China.
  • Chen M; The Second Affiliated Hospital of Chengdu Medical College, 416 Nuclear Industry Hospital, Chengdu 610057, Sichuan, People's Republic of China.
  • Du H; Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • Zhang Y; Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • Wu D; Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • Xiang X; Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • Zhang J; College of Computer Science, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • Jiang N; National Clinical Research Center for Geriatrics, Med-X Center for Manufacturing, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • He H; Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • Song Y; Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • Xiang Z; Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • He C; Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • Zhou Z; Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • Zeng J; Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • Xiang Y; School of Materials and Energy, University of Electronic Science and Technology of China, 2006 Xiyuan Ave., West High-Tech Zone, Chengdu 611731, Sichuan, China.
  • Huang SS; Department of Orthopedic Surgery and Orthopedic Research Institute, Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
  • Lin Y; Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
Nano Lett ; 23(18): 8816-8826, 2023 09 27.
Article en En | MEDLINE | ID: mdl-37459451
Sarcopenia is known as age-related muscle atrophy, which influences over a quarter of the elderly population worldwide. It is characterized by a progressive decline in muscle mass, strength, and performance. To date, clinical treatments in sarcopenia are limited to rehabilitative interventions and dietary supplements. Tetrahedral framework nucleic acids (tFNAs) represent a novel kind of DNA-based nanomaterial with superior antiapoptosis capacity in cells, tissues, organs, and systems. In our study, the therapeutic effect of tFNAs treatment on sarcopenia was evaluated both in vivo and in vitro. Results from muscular biophysiological characteristics demonstrated significant improvement in muscle function and endurance in the aged mouse model, and histologic examinations also showed beneficial morphological changes in muscle fibers. In vitro, DEX-induced sarcopenic myotube atrophy was also ameliorated through the inhibition of mitochondria-mediated cell apoptosis. Collectively, tFNAs treatment might serve as an alternative option to deal with sarcopenia in the near future.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ácidos Nucleicos / Sarcopenia Tipo de estudio: Prognostic_studies Idioma: En Revista: Nano Lett Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ácidos Nucleicos / Sarcopenia Tipo de estudio: Prognostic_studies Idioma: En Revista: Nano Lett Año: 2023 Tipo del documento: Article