A conserved arginine within the &#945;C-helix of Erk1/2 is a latch of autoactivation and of oncogenic capabilities.

Soudah, Nadine; Baskin, Alexey; Smorodinsky-Atias, Karin; Beenstock, Jonah; Ganon, Yifat; Hayouka, Ruchama; Aboraya, Mohammed; Livnah, Oded; Ilouz, Ronit; Engelberg, David

A conserved arginine within the αC-helix of Erk1/2 is a latch of autoactivation and of oncogenic capabilities.

Soudah, Nadine; Baskin, Alexey; Smorodinsky-Atias, Karin; Beenstock, Jonah; Ganon, Yifat; Hayouka, Ruchama; Aboraya, Mohammed; Livnah, Oded; Ilouz, Ronit; Engelberg, David.

Afiliación

Soudah N; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel.
Baskin A; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel.
Smorodinsky-Atias K; School of Neurobiology, Biochemistry and Biophysics, Tel Aviv University, Tel Aviv-Yafo, Israel.
Beenstock J; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel.
Ganon Y; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel.
Hayouka R; The Robert H. Smith Institute of Plant Sciences and Genetics in Agriculture, The Hebrew University of Jerusalem, Rehovot, Israel.
Aboraya M; The Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
Livnah O; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel; The Wolfson Centre for Applied Structural Biology, Jerusalem, Israel.
Ilouz R; The Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
Engelberg D; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel; Singapore-HUJ Alliance for Research and Enterprise, Mechanisms of Liver Inflammatory Diseases Program, National University of Singapore, Singapore; Department of Microbiology and

J Biol Chem ; 299(9): 105072, 2023 09.

Article en En | MEDLINE | ID: mdl-37474104

Asunto(s)

Arginina; Proteína Quinasa 1 Activada por Mitógenos; Proteína Quinasa 3 Activada por Mitógenos; Fosforilación; Arginina/metabolismo; Humanos; Animales; Ratones; Línea Celular; Células HEK293; Activación Enzimática/genética; Mutación; Saccharomyces cerevisiae/enzimología; Saccharomyces cerevisiae/genética; Proteína Quinasa 1 Activada por Mitógenos/química; Proteína Quinasa 1 Activada por Mitógenos/genética; Proteína Quinasa 1 Activada por Mitógenos/metabolismo; Proteína Quinasa 3 Activada por Mitógenos/química; Proteína Quinasa 3 Activada por Mitógenos/genética; Proteína Quinasa 3 Activada por Mitógenos/metabolismo; Estructura Terciaria de Proteína; Modelos Moleculares; Cristalización; Secuencia de Aminoácidos

Palabras clave

ERK; MAP kinase; activation loop; active variants; autophosphorylation; eukaryotic protein kinases

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Arginina / Proteína Quinasa 1 Activada por Mitógenos / Proteína Quinasa 3 Activada por Mitógenos Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google