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Ocular surface inflammation and ectatic corneal disorders.
Erdinest, Nir; Wajnsztajn, Denise; London, Naomi; Solomon, Abraham.
Afiliación
  • Erdinest N; Department of Ophthalmology, Hadassah-Hebrew University Medical Center.
  • Wajnsztajn D; Department of Ophthalmology, Hadassah-Hebrew University Medical Center.
  • London N; Private Practice, Jerusalem, Israel.
  • Solomon A; Department of Ophthalmology, Hadassah-Hebrew University Medical Center.
Curr Opin Allergy Clin Immunol ; 23(5): 430-437, 2023 10 01.
Article en En | MEDLINE | ID: mdl-37490610
PURPOSE OF REVIEW: Inflammatory mediators are a focus of recent corneal ectasia (CE) research and are a profound, modifiable contributor to CE in general and keratoconus (KC) in particular, opening a path to explore new methods of control. As advanced imaging technology and expanded population screening allow for earlier detection, the possibility of early intervention can profoundly change the prognosis of CE. RECENT FINDINGS: Significant increases in the inflammatory mediators and immune components have been observed in the cornea, tear fluid, and blood of ectasia patients, while inflammation dampeners such as vitamin D and their receptors are reduced. Atopy and allergy have a strong association with KC, known to increase itch factors and stimulate eye rubbing, a risk factor in ectasia pathogenesis. Management of atopy or allergic conditions and topical anti-inflammatories has helped stabilize CE disease. SUMMARY: Strategies such as monitoring inflammatory factors and using immune or inflammatory modulators, including managing subclinical inflammation, may be clinically beneficial in stabilizing the disease and improving outcomes. The detected factors are biomarkers, but as yet unproven to be sensitive or specific enough to be considered biomarkers for early detection of CE. The establishment of such biomarkers could improve the therapeutic outcome.
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Hipersensibilidad Inmediata / Queratocono Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Idioma: En Revista: Curr Opin Allergy Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Hipersensibilidad Inmediata / Queratocono Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Idioma: En Revista: Curr Opin Allergy Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article