Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RAR&#945;.

Usui, Shinya; Zhu, Qiunan; Komori, Hisakazu; Iwamoto, Yui; Nishiuchi, Takumi; Shirasaka, Yoshiyuki; Tamai, Ikumi

Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα.

Usui, Shinya; Zhu, Qiunan; Komori, Hisakazu; Iwamoto, Yui; Nishiuchi, Takumi; Shirasaka, Yoshiyuki; Tamai, Ikumi.

Afiliación

Usui S; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.
Zhu Q; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.
Komori H; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.
Iwamoto Y; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.
Nishiuchi T; Research Center for Experimental Modeling of Human Disease, Kanazawa University, Ishikawa, 920-0934, Japan.
Shirasaka Y; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.
Tamai I; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan. Electronic address: tamai@p.kanazawa-u.ac.jp.

Drug Metab Pharmacokinet ; 52: 100512, 2023 Oct.

Article en En | MEDLINE | ID: mdl-37517353

Asunto(s)

Vesículas Extracelulares; Malus; MicroARNs; Simportadores; Humanos; Factores de Transcripción/genética; Factores de Transcripción/metabolismo; Regulación hacia Abajo; Malus/genética; Malus/metabolismo; Regiones no Traducidas 3'; Ácidos y Sales Biliares; MicroARNs/genética; Vesículas Extracelulares/genética; Vesículas Extracelulares/metabolismo; Simportadores/genética; Simportadores/metabolismo; Transportadores de Anión Orgánico Sodio-Dependiente/genética; Transportadores de Anión Orgánico Sodio-Dependiente/metabolismo

Palabras clave

ASBT; Apple; Bile acid; Extracellular vesicle; Food effect; RARα; microRNA

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Malus / Simportadores / MicroARNs / Vesículas Extracelulares Tipo de estudio: Prognostic_studies Idioma: En Revista: Drug Metab Pharmacokinet Asunto de la revista: FARMACOLOGIA / METABOLISMO Año: 2023 Tipo del documento: Article

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