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Relationship Between LTA4H Promotor Polymorphism and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and Its Prevention With Prednisone.
Stek, Cari; Shey, Muki; Mnika, Khuthala; Schutz, Charlotte; Thienemann, Friedrich; Wilkinson, Robert J; Lynen, Lutgarde; Meintjes, Graeme.
Afiliación
  • Stek C; Wellcome Center for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
  • Shey M; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
  • Mnika K; Department of Medicine, University of Cape Town, Cape Town, South Africa.
  • Schutz C; Wellcome Center for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
  • Thienemann F; Department of Medicine, University of Cape Town, Cape Town, South Africa.
  • Wilkinson RJ; Division of Human Genetics, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Lynen L; Wellcome Center for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
  • Meintjes G; Department of Medicine, University of Cape Town, Cape Town, South Africa.
Open Forum Infect Dis ; 10(7): ofad379, 2023 Jul.
Article en En | MEDLINE | ID: mdl-37520416
The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between LTA4H genotype and TB-IRIS incidence or prednisone efficacy.
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Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Open Forum Infect Dis Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Open Forum Infect Dis Año: 2023 Tipo del documento: Article