Your browser doesn't support javascript.
loading
Polyhydroxyalkanoates: the natural biopolyester for future medical innovations.
Ren, Zi-Wei; Wang, Ze-Yu; Ding, Yan-Wen; Dao, Jin-Wei; Li, Hao-Ru; Ma, Xue; Yang, Xin-Yu; Zhou, Zi-Qi; Liu, Jia-Xuan; Mi, Chen-Hui; Gao, Zhe-Chen; Pei, Hua; Wei, Dai-Xu.
Afiliación
  • Ren ZW; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi'an, 710069, China. weidaixu@nwu.edu.cn.
  • Wang ZY; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi'an, 710069, China. weidaixu@nwu.edu.cn.
  • Ding YW; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi'an, 710069, China. weidaixu@nwu.edu.cn.
  • Dao JW; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi'an, 710069, China. weidaixu@nwu.edu.cn.
  • Li HR; Dehong Biomedical Engineering Research Center, Dehong Teachers' College, Dehong, 678400, China.
  • Ma X; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi'an, 710069, China. weidaixu@nwu.edu.cn.
  • Yang XY; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi'an, 710069, China. weidaixu@nwu.edu.cn.
  • Zhou ZQ; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi'an, 710069, China. weidaixu@nwu.edu.cn.
  • Liu JX; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi'an, 710069, China. weidaixu@nwu.edu.cn.
  • Mi CH; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi'an, 710069, China. weidaixu@nwu.edu.cn.
  • Gao ZC; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi'an, 710069, China. weidaixu@nwu.edu.cn.
  • Pei H; Department of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
  • Wei DX; Department of Clinical Laboratory, The Second Affiliated Hospital, Hainan Medical University, Haikou, 570311, China. phzmh61@aliyun.com.
Biomater Sci ; 11(18): 6013-6034, 2023 Sep 12.
Article en En | MEDLINE | ID: mdl-37522312
Polyhydroxyalkanoates (PHAs) are a family of natural microbial biopolyesters with the same basic chemical structure and diverse side chain groups. Based on their excellent biodegradability, biocompatibility, thermoplastic properties and diversity, PHAs are highly promising medical biomaterials and elements of medical devices for applications in tissue engineering and drug delivery. However, due to the high cost of biotechnological production, most PHAs have yet to be applied in the clinic and have only been studied at laboratory scale. This review focuses on the biosynthesis, diversity, physical properties, biodegradability and biosafety of PHAs. We also discuss optimization strategies for improved microbial production of commercial PHAs via novel synthetic biology tools. Moreover, we also systematically summarize various medical devices based on PHAs and related design approaches for medical applications, including tissue repair and drug delivery. The main degradation product of PHAs, 3-hydroxybutyrate (3HB), is recognized as a new functional molecule for cancer therapy and immune regulation. Although PHAs still account for only a small percentage of medical polymers, up-and-coming novel medical PHA devices will enter the clinical translation stage in the next few years.
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Polihidroxialcanoatos Idioma: En Revista: Biomater Sci Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Polihidroxialcanoatos Idioma: En Revista: Biomater Sci Año: 2023 Tipo del documento: Article