Facile access to S-methyl dithiocarbamates with sulfonium or sulfoxonium iodide as a methylation reagent.
Org Biomol Chem
; 21(32): 6474-6478, 2023 Aug 16.
Article
en En
| MEDLINE
| ID: mdl-37523154
ABSTRACT
Efficient access to S-methyl dithiocarbamates was achieved with sulfonium or sulfoxonium iodide as a methylation reagent. This method is reliable for the synthesis of dithiocarbamates from primary or secondary amines, with sulfoxonium iodide demonstrating more robust methylation capability than sulfonium iodide. Moreover, it also enables facile access to S-trideuteromethyl dithiocarbamates via sulfoxonium metathesis between sulfoxonium iodide and DMSO-d6 with high yields.
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Base de datos:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2023
Tipo del documento:
Article