(R,S)-trihexyphenidyl, acting via a muscarinic receptor-independent mechanism, inhibits hippocampal glutamatergic and GABAergic synaptic transmissions: Potential relevance for treatment of organophosphorus intoxication.

Aracava, Yasco; Albuquerque, Edson X; Pereira, Edna F R

Aracava, Yasco; Albuquerque, Edson X; Pereira, Edna F R.

Afiliación

Aracava Y; Division of Translational Toxicology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Albuquerque EX; Division of Translational Toxicology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Pereira EFR; Division of Translational Toxicology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: epereira@som.umaryland.edu.

Neuropharmacology ; 239: 109684, 2023 11 15.

Article en En | MEDLINE | ID: mdl-37549771

Asunto(s)

Acetilcolinesterasa; Trihexifenidilo; Ratas; Animales; Trihexifenidilo/farmacología; Ratas Sprague-Dawley; Acetilcolinesterasa/farmacología; Transmisión Sináptica; Hipocampo; Receptores Muscarínicos; Derivados de Atropina/farmacología; Convulsiones

Palabras clave

Muscarinic receptors; NMDA receptors; Nicotinic receptors; Primary cultures; Voltage clamp

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Acetilcolinesterasa / Trihexifenidilo Idioma: En Revista: Neuropharmacology Año: 2023 Tipo del documento: Article

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